Aviapen may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Benzylpenicillin potassium (a derivative of Benzylpenicillin) is reported as an ingredient of Aviapen in the following countries:
International Drug Name Search
Moducrin may be available in the countries listed below.
Amiloride hydrochloride dihydrate (a derivative of Amiloride) is reported as an ingredient of Moducrin in the following countries:
Hydrochlorothiazide is reported as an ingredient of Moducrin in the following countries:
Timolol maleate (a derivative of Timolol) is reported as an ingredient of Moducrin in the following countries:
International Drug Name Search
See also: Generic Loestrin 21 1.5/30, Generic Loestrin 21 1/20, Generic Loestrin Fe 1.5/30, Generic Loestrin Fe 1/20
Loestrin 24 Fe is a brand name of ethinyl estradiol/norethindrone, approved by the FDA in the following formulation(s):
A generic version of Loestrin 24 Fe has been approved by the FDA. However, this does not mean that the product will necessarily be commercially available - possibly because of drug patents and/or drug exclusivity. The following products are equivalent to Loestrin 24 Fe and have been approved by the FDA:
Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Loestrin 24 Fe. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.
See also: About generic drugs.
Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims.
Diarryl may be available in the countries listed below.
Nifuroxazide is reported as an ingredient of Diarryl in the following countries:
International Drug Name Search
In the US, Synemol is a member of the drug class topical steroids and is used to treat Atopic Dermatitis, Dermatitis and Lichen Sclerosus.
Fluocinolone Acetonide is reported as an ingredient of Synemol in the following countries:
International Drug Name Search
Class: Benzylamines
ATC Class: D01AE23
VA Class: DE102
Chemical Name: N- (4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-1-naphthalenemethanamine hydrochloride
Molecular Formula: C23H27N•ClH
CAS Number: 101827-46-7
Brands: Lotrimin Ultra, Mentax
Antifungal; benzylamine.1 2 3 4 5 7 8 9 10 11
Treatment of tinea corporis (body ringworm) and tinea cruris (jock itch) caused by Epidermophyton floccosum, Trichophyton mentagrophytes, T. rubrum, or T. tonsurans.1 7 8 9 18
Treatment of tinea pedis (athlete’s foot) caused by E. floccosum, T. mentagrophytes, T. rubrum, or T. tonsurans.1 7 8 9 18
Available for self-medication (OTC use) for treatment of tinea corporis, tinea cruris, and tinea pedis.18
Do not use for scalp or nail infections.18
Has not been evaluated in immunocompromised patients.1
Topical antifungals usually effective for treatment of uncomplicated tinea corporis or tinea cruris.12 13 14 15 16 An oral antifungal may be necessary when tinea corporis or tinea cruris is extensive, dermatophyte folliculitis is present, infection is chronic or does not respond to topical therapy, or patient is immunocompromised because of coexisting disease or concomitant therapy.12 13 14 15 16
Topical antifungals usually effective for treatment of uncomplicated tinea pedis.12 13 14 15 16 An oral antifungal may be necessary for treatment of hyperkeratotic areas on palms and soles,13 16 for chronic moccasin-type tinea pedis,12 13 15 and for tinea unguium (fingernail or toenail dermatophyte infections, onychomycosis).
Treatment of pityriasis (tinea) versicolor caused by Malassezia furfur (Pityrosporum orbiculare or P. ovale).1
Has not been evaluated in immunocompromised patients.1
Topical antifungals generally effective;12 15 19 20 an oral antifungal (with or without a topical antifungal) may be necessary in patients who have extensive or severe infections or have failed to respond to or have frequent relapses with topical therapy.15 19
Apply topically to the skin as a 1% cream.1 18
Avoid contact with eyes, nose, mouth, and other mucous membranes.1 18
Clean affected areas with soap and water; dry thoroughly prior to applying cream.1 18 May be applied after bathing.1
Massage cream gently into affected areas.1 18 Wash hands after application process.1 18
Do not use occlusive dressings or wrappings.1
When treating tinea pedis, pay special attention to spaces between toes.18 Also, wear well-fitting, ventilated shoes and change shoes and socks at least once daily.18
Children ≥12 years of age: Apply to affected area and immediately surrounding skin once daily for 2 weeks.1 18
If clinical improvement does not occur after treatment, diagnosis and therapy should be reevaluated.1
Children ≥12 years of age: Apply to affected area and immediately surrounding skin twice daily (morning and night) for 7 days or once daily for 4 weeks.1 18
Some data indicate the 7-day regimen is less effective than the 4-week regimen; this should be considered when selecting dosage regimen for patients at risk for developing bacterial cellulitis of lower extremities associated with interdigital cracking/fissuring.1
If clinical improvement does not occur after treatment, diagnosis and therapy should be reevaluated.1
Children ≥12 years of age: Apply to affected area and immediately surrounding skin once daily for 2 weeks.1
If clinical improvement does not occur after treatment, diagnosis and therapy should be reevaluated.1
Apply to affected area and immediately surrounding skin once daily for 2 weeks.1 18
If clinical improvement does not occur after treatment, diagnosis and therapy should be reevaluated.1
Apply to affected area and immediately surrounding skin twice daily (morning and night) for 7 days or once daily for 4 weeks.1 18
Some data indicate the 7-day regimen is less effective than the 4-week regimen; this should be considered when selecting dosage regimen for patients at risk for developing bacterial cellulitis of lower extremities associated with interdigital cracking/fissuring.1
If clinical improvement does not occur after treatment, diagnosis and therapy should be reevaluated.1
Apply to affected area and immediately surrounding skin once daily for 2 weeks. 1
If clinical improvement does not occur, diagnosis and therapy should be reevaluated.1
No special population dosage recommendations at this time.1
Known hypersensitivity to butenafine or any ingredient in the formulation.1
For external use only.1 18 Use only for topical application to the skin; not for ophthalmic or intravaginal use.1 18
Avoid contact with eyes, nose, mouth, and other mucous membranes.1 18
If contact with the eye(s) occurs, wash with large amounts of water; consult a clinician if ocular irritation persists.1 18
Do not use for scalp or nail infections.18
If irritation or sensitivity occurs, discontinue drug and initiate appropriate therapy.1 18
Contact dermatitis has been reported rarely.1
Use with caution in patients hypersensitive to allylamine antifungals (e.g., naftifine, terbinafine) since cross-sensitivity may occur.1
Prior to use, confirm diagnosis by direct microscopic examination of scrapings from infected tissue mounted in potassium hydroxide (KOH) or by culture.1
Category B.1
Not known whether distributed into milk following topical application.1 Use with caution and avoid applying to the breast of nursing women.1
Safety and efficacy not established in children <12 years of age.1
Burning/stinging, itching, worsening of condition.1
No formal drug interaction studies to date.1
Percutaneous absorption occurs following topical application of 1% cream.1 Total amount of dose absorbed into systemic circulation following topical application has not been quantified.1
Not known whether distributed into milk following topical application.1
Systemically absorbed drug is metabolized; principal metabolite in urine is formed through hydroxylation at the terminal t-butyl side-chain.1
After absorption through skin, a biphasic decline occurs with estimated half-lives of 35 and >150 hours, respectively.1
5–30°C.1 18
Benzylamine antifungal1 2 3 4 5 7 8 9 10 11 structurally and pharmacologically related to allylamine antifungals (e.g., naftifine, terbinafine).1 4 7 8 9 10 11
May be fungicidal in certain concentrations or against susceptible organisms (e.g., dermatophytes).1 4 5 7 8 9 10 11
Presumably exerts its antifungal activity by altering cellular membranes, resulting in increased membrane permeability, and growth inhibition.1 2 3 11
Appears to interfere with sterol biosynthesis by inhibiting the enzyme squalene monooxygenase (squalene 2,3-epoxidase),10 which results in decreased amounts of sterols, especially ergosterol,2 4 8 9 11 and a corresponding accumulation of squalene (the usual substrate of the enzyme) in the cells.7 11
Dermatophytes: Active in vitro against Epidermophyton floccosum,1 Microsporum canis,4 5 11 Trichophyton mentagrophytes,1 3 4 5 11 T. rubrum,1 and T. tonsurans.1
Other fungi: Active in vitro against Malassezia furfur.1 Also active in vitro against Candida albicans2 7 11 and C. parapsilosis.2 7 11
Importance of completing full course of treatment, even if symptoms improve.1 18
Importance of contacting clinician if improvement does not occur by end of prescribed treatment period.1
Importance of notifying clinician if condition worsens or treated area shows signs of increased irritation, redness, itching, burning, blistering, swelling, or oozing.1 18
Importance of applying to affected areas as directed and avoiding contact with eyes, nose, mouth, or other mucous membranes.1 18
Advise patients to wash their hands after touching the affected areas so that the infection is not spread to other areas of the body or to other individuals.1 18
For patients with tinea pedis (athlete’s foot), importance of wearing well-fitting, ventilated shoes and changing socks at least once daily.18
Importance of not using occlusive dressings, unless otherwise directed by clinician.1
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.1
Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed.1
Importance of informing patients of other important precautionary information.1 (See Cautions.)
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
Topical | Cream | 1% | Lotrimin Ultra | Schering-Plough |
Mentax | Bertek |
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions August 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
1. Bertek Pharmaceuticals Inc. Mentax (butenafine HCl) cream, 1% prescribing information. Morgantown, WV; 2001 Jun 6.
2. Iwatani W, Arika T, Yamaguchi H. Two mechanisms of butenafine action in Candida albicans. Antimicrob Agents Chemother. 1993; 37:785-8.
3. Arika T, Hase T, Yokoo M. Anti-Trichophyton mentagrophytes activity and percutaneous permeation of butenafine in guinea pigs. Antimicrob Agents Chemother. 1993; 37:363-5. [PubMed 8452371]
4. Arika T, Yokoo M, Hase T et al. Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs. Antimicrob Agents Chemother. 1990; 34:2250-53. [PubMed 2073116]
5. Arika T, Yokoo M, Maeda T et al. Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental tinea pedis in guinea pigs. Antimicrob Agents Chemother. 1990; 34:2254-5. [PubMed 2073117]
6. Uchida K, Kudoh M, Yamaguchi H. A study on effectiveness of treatment and prevention of relapse using topical administration of terbinafine in a guinea pig model for tinea pedis. Jpn J Antibiot. 1994; 47:1407-12. [PubMed 7807700]
7. Tschen E, Elewski B, Gorsulowsky et al. Treatment of interdigital tinea pedis with a 4-week once-daily regimen of butenafine hydrochloride 1% cream. J Am Acad Dermatol. 1997; 36:S9-14. [IDIS 382256] [PubMed 9039199]
8. Lesher JL, Babel DE, Stewart DM et al. Butenafine 1% cream in the treatment of tinea cruris: a multicenter, vehicle-controlled, double-blind trial. J Am Acad Dermatol. 1997; 36:S20-4. [IDIS 382258] [PubMed 9039201]
9. Savin R, De Villez RL, Elewski B et al. One-week therapy with twice-daily butenafine 1% cream versus vehicle in the treatment of tinea pedis: a multicenter, double-blind trial. J Am Acad Dermatol. 1997; 36:S15-19.
10. Odom RB. Update on topical therapy for superficial fungal infections: focus on butenafine. J Am Acad Dermatol. 1997; 36:S1-2.
11. Brennan B, Leyden JL. Overview of topical therapy for common superficial fungal infections and the role of new topical agents. J Am Acad Dermatol. 1997; 36:53-8. [PubMed 8996261]
12. Gupta AK, Einarson TR, Summerbell RC et al. An overview of topical antifungal therapy in dermatomycoses: a North American perspective. Drugs. 1998; 55:645-74. [PubMed 9585862]
13. Piérard GE, Arrese JE, Piérard-Franchimont C. Treatment and prophylaxis of tinea infections. Drugs. 1996; 52:209-24. [PubMed 8841739]
14. Lesher JL. Recent developments in antifungal therapy. Dermatol Clin. 1996; 14:163-9. [PubMed 8821170]
15. Hay RJ. Dermatophytosis and other superficial mycoses. In: Mandel GL, Douglas RG Jr, Bennett JE, eds. Principles and practices of infectious disease. 4th ed. New York: Churchill Livingston; 1995: 2375-86.
16. Drake LA, Dincehart SM, Farmer ER et al. Guidelines of care for superficial mycotic infections of the skin: tinea corporis, tinea cruris, tinea faciei, tinea manuum, and tinea pedis. J Am Acad Dermatol. 1996; 34:282-6. [IDIS 363962] [PubMed 8642094]
17. Reviewers’ comments (personal observations) on Sulconazole 84:04.08.
18. Schering-Plough. Lotrimin Ultra (butenafine hydrochloride) 1% cream prescribing information. Memphis, TN; 2001.
19. Assaf RR. The superficial mycoses. Dermatol Clin. 1996; 14:57-67. [PubMed 8821158]
20. Drake LA, Dinehart SM, Farmer ER. Guidelines of care for superficial mycotic infections of the skin: pityriasis (tinea) versicolor. J Am Acad Dermatol. 1996; 34:287-9. [IDIS 363963] [PubMed 8642095]
Doxorubicin Pliva may be available in the countries listed below.
Doxorubicin hydrochloride (a derivative of Doxorubicin) is reported as an ingredient of Doxorubicin Pliva in the following countries:
International Drug Name Search
Fluoxetina Generics may be available in the countries listed below.
Fluoxetine hydrochloride (a derivative of Fluoxetine) is reported as an ingredient of Fluoxetina Generics in the following countries:
International Drug Name Search
Pantogen may be available in the countries listed below.
Pantoprazole is reported as an ingredient of Pantogen in the following countries:
International Drug Name Search
Alanta may be available in the countries listed below.
Aldioxa is reported as an ingredient of Alanta in the following countries:
International Drug Name Search
Prestole may be available in the countries listed below.
Hydrochlorothiazide is reported as an ingredient of Prestole in the following countries:
Triamterene is reported as an ingredient of Prestole in the following countries:
International Drug Name Search
