Vexol 1%

VEXOL 1% (10 mg/ml)


EYE DROPS, SUSPENSION

Rimexolone

Read all of this leaflet carefully before you start using this medicine.

• This medicine has been prescribed for you personally. You should not pass it on to other people. It may harm them, even if their symptoms are the same as yours.


• 
  Keep this leaflet. You may need to read it again. If you still have questions after reading it, please ask your doctor or your pharmacist.

The active substance is rimexolone 10 mg/ml.

Other ingredients: benzalkonium chloride 0.1 mg/ml as a preservative, mannitol, carbomer, polysorbate 80, disodium edetate, sodium chloride and purified water. Very small amounts of hydrochloric acid and/or sodium hydroxide may have been added to regulate the acidity/alkalinity of the product to ensure comfort in the eye.

The marketing authorisation holder for VEXOL is

Alcon Laboratories (UK) Ltd.

Boundary Way

Hemel Hempstead

Herts

HP2 7UD

United Kingdom

The manufacturer of VEXOL is

Alcon-Couvreur NV

Rijksweg 14

B-2870 Puurs

Belgium

What Vexol Is And What It Is Used For

Vexol 1% (10 mg/ml) eye drops contain a substance called rimexolone, which is a type of substance known as an anti-inflammatory corticosteroid. Anti-inflammatory corticosteroids are types of medicines that help prevent or reduce redness, swelling and soreness in your eye.

If you have been prescribed this medicine then you will be suffering from inflammation (redness, soreness or swelling) in your eye. This inflammation may be caused as a result of an operation on your eye or it may be caused by an infection or by something entering into your eye. Vexol helps to prevent or reduce this inflammation.

Vexol 1% (10 mg/ml) is supplied as a white to off-white suspension in plastic dropper bottles containing 3 ml, 5 ml or 10 ml of solution.

Before You Use Vexol

In some circumstances, this medicine may not be suitable for you and your doctor may wish to give you a different medicine. If your doctor is unaware that you suffer from any of the following conditions please inform your doctor before starting to take this medicine.

• If you have an infection in your eye caused by a virus, fungi or mycobacteria.


• If you have a red eye where the cause is not known or an amoebic infection.


• If you have a severe eye infection.


• If you have kidney or liver problems.


• If you have ever had to stop taking a medicine because you were allergic to it.


• If you are pregnant or intending to become pregnant.


• If you are breast feeding a baby.

Vexol has not been shown to have any effects on any other medicines that you may also be taking, however, you should make sure your doctor knows what other medicines you are taking before using Vexol.

• Since the product contains benzalkonium chloride as a preservative, which has been known to discolour soft contact lenses, you must not wear soft contact lenses while using this medicine.


• If your sight is affected in any way following the use of Vexol you should not drive or operate machinery.

How To Use Vexol

The normal dosage i.e. how often you should use Vexol, will depend on the cause of your inflammation. The normal dosage instructions for each condition for which Vexol is prescribed are listed below.

Your own dosage instructions will be specified on the label attached to the outer carton of your medicine. If they are not, or you are not sure, then ask your doctor or pharmacist. It is important that you use Vexol as instructed by your doctor.

Adults and elderly:

Post-operative inflammation

Apply one drop in the affected eye four times daily, beginning 24 hours after your operation and continuing throughout the first 2 weeks following your operation.

Steroid responsive inflammation

Apply one drop in the affected eye four times daily or more often (as indicated by your doctor).

Uveitis

• 
  First Week
  


• Apply one drop in the affected eye every hour during the daytime.

• 
  Second Week
  


• Apply one drop every two hours during the daytime.

• 
  Third Week
  


• Apply one drop four times daily.

• 
  Fourth Week
  


• Apply one drop twice daily for the first four days and then apply one drop once daily for the last three days.

Children:

The safe use of this medicine in children has not been demonstrated. Therefore, Vexol is not recommended for use in children.

Only use Vexol for dropping in your eyes.

How to put the drops in your eye

By following the 10 steps listed below, you will ensure that your eye drops are being used correctly and to the best effect.

• 
  1. Wash your hands before using Vexol.


• 
  2. Sit down in front of a mirror so that you can see what you are doing.


• 
  3. Shake the bottle well and then remove the cap from the bottle.


• 
  4. Make sure the dropper tip does not touch anything as this may contaminate the contents.


• 
  5. Hold the bottle upside down in one hand between your thumb and middle finger.


• 
  6. Using the forefinger of your other hand, gently pull down the lower eyelid of the affected eye.


• 
  7. Place the dropper bottle tip close to, but not touching, your eye and gently tap the base of the bottle with your forefinger so that one drop falls into the gap between the eye and the lower lid.


• 
  8. Now release the lower eyelid, and blink a few times to make sure the whole of the eye is covered by the liquid.


• 
  9. Repeat steps 5 to 8 above, for the other eye, if necessary.


• 
  10. Replace and tightly close the cap on the dropper bottle.

What you should do if you miss a dose of Vexol

If you miss a dose, DO NOT WORRY. Just put in the next dose when it is due.

What you should do if you put too much Vexol in your eye

If you put too much of this medicine in your eye(s), it can be washed out with warm water.

Vexol 1% Side Effects

• You may experience some or all of the following reactions in your eye(s) :
  
  
  • Common (may affect 1-3% of people):
    
    
    • Blurred vision - Discharge - Discomfort - Pain - Increased pressure in your eye - Foreign body (gritty) sensation.
  • Uncommon (may affect less than 1% of people) :
    
    
    • Redness of the eye or inside the eyelid - Itching - Sticky sensation - Dryness - Swelling - Increased tear production - Sensitivity to light - Irritation - Staining or inflammation of the cornea.


• You may also experience reactions in other areas of your body including:
  
  
  • Uncommon (may affect less than 1% of people) :
    
    
    • Eyebrow ache - Headache - Low blood pressure - Inflamed/blocked nose - Inflamed/sore throat - Bad taste in your mouth.


• If you experience any of the reactions listed above, or any others not listed, after using Vexol, tell your doctor and follow his/her advice.

Storing Vexol

• Keep Vexol in a safe place out of the reach and sight of children.


• Do not store above 30°C. Do not freeze.


• Do not use this medicine after the expiry date shown as "EXP" on the bottle and carton.


• Once the bottle has been opened then the eye drops must be discarded one month after first opening.

This leaflet was last changed January 2001.

VEXOL is a registered trademark of N.V. Organon.

Further information

If you have any other questions about your medicines you should ask a doctor or pharmacist.

APAP/Pentazocine HCl

Generic Name: pentazocine and acetaminophen (Oral route)

a-seet-a-MIN-oh-fen, pen-TAZ-oh-seen hye-droe-KLOR-ide

Oral route(Tablet)

Talacen(R) contains pentazocine hydrochloride and acetaminophen. Acetaminophen has been associated with acute liver failure, with some cases resulting in liver transplant and death. Most cases of liver injury were associated with acetaminophen use at doses exceeding 4000 mg/day, and often involved more than 1 acetaminophen-containing product

Commonly used brand name(s)

In the U.S.

• APAP/Pentazocine HCl


• Talacen

Available Dosage Forms:

• Tablet

Therapeutic Class: Opioid Agonist/Antagonist/Acetaminophen Combination

Pharmacologic Class: Pentazocine

Uses For APAP/Pentazocine HCl

Pentazocine and acetaminophen combination is used to relieve mild to moderate pain. When used together, the combination provides better pain relief than either medicine used alone. In some cases, you may get relief with lower doses of each medicine.

Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage.

Pentazocine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain. When pentazocine is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

This medicine is available only with your doctor's prescription.

Before Using APAP/Pentazocine HCl

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of pentazocine and acetaminophen combination in children younger than 12 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pentazocine and acetaminophen combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving pentazocine and acetaminophen combination.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil


• Alphaprodine


• Codeine


• Dihydrocodeine


• Fentanyl


• Fospropofol


• Hydrocodone


• Hydromorphone


• Levorphanol


• Meperidine


• Methadone


• Morphine


• Morphine Sulfate Liposome


• Oxycodone


• Oxymorphone


• Propoxyphene


• Selegiline


• Sibutramine


• Sufentanil


• Tapentadol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acenocoumarol


• Carbamazepine


• Fluoxetine


• Isoniazid


• Phenytoin


• Warfarin


• Zidovudine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Cabbage


• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Addison's disease (adrenal gland problem) or


• Alcohol abuse, or history of or


• Asthma, severe or


• Brain tumor, history of or


• Breathing problems (e.g., hypercapnia, hypoxia), severe or


• Cholecystitis (inflammation of the gallbladder) or


• Chronic obstructive pulmonary disease (COPD) or


• Cor pulmonale (serious heart condition) or


• Drug dependence, especially with narcotics, or history of or


• Enlarged prostate (BPH, prostatic hypertrophy) or


• Head injuries, history of or


• Hypothyroidism (an underactive thyroid) or


• Increased pressure in the head or


• Intestinal or bowel blockage or


• Kyphoscoliosis (curvature of spine that can cause breathing problems), severe or


• Mental illness, history of or


• Pancreatitis (inflammation of the pancreas) or


• Respiratory depression (very slow breathing) or


• Stomach problems, severe—Use with caution. May increase risk for more serious side effects.

• Heart attack, recent or


• Heart or blood vessel disease or


• Hypertension (high blood pressure) or


• Porphyria (an enzyme problem) or


• Seizures, history of—Use with caution. May make these conditions worse.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• Sulfite allergy—Should not be used in patients with this condition.

Proper Use of pentazocine and acetaminophen

This section provides information on the proper use of a number of products that contain pentazocine and acetaminophen. It may not be specific to APAP/Pentazocine HCl. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdosage. Liver damage can occur if large amounts of acetaminophen are taken for a long time.

This combination medicine contains acetaminophen (Tylenol®). Carefully check the labels of all other medicines you are using, because they may also contain acetaminophen. It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours).

You may take this medicine with or without food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For mild to moderate pain:
    
    • Adults, teenagers, and children 12 years of age and older—One tablet every 4 hours as needed. Your doctor may adjust your dose if needed. However, the dose is usually not more than 6 tablets per day.
    
    
    • Children younger than 12 years of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Make sure you store the medicine in a safe and secure place to prevent others from getting it.

Precautions While Using APAP/Pentazocine HCl

It is very important that your doctor check the progress of you or your child while you are using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you or your child should continue to take it.

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you or your child have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Also, there may be a greater risk of liver damage if you drink three or more alcoholic beverages while you are taking acetaminophen. Do not drink alcoholic beverages, and check with your doctor before you or your child take any of the medicines listed above while you are using this medicine.

Make sure your doctor knows if you or your child have received narcotic medicines (e.g., methadone) in the past. Some patients who have had received narcotic pain medicines, have experienced withdrawal symptoms after receiving pentazocine.

Check with your doctor if you or your child have confusion about identity, place, and time; mood or mental changes; or seeing things that are not there while taking this medicine.

This medicine may be habit-forming. If you or your child feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

This medicine may make you dizzy, drowsy, or lightheaded. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you or your child to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

If you or your child have been using this medicine regularly for several weeks or longer, do not change your dose or suddenly stop using it without checking with your doctor. Your doctor may want you or your child to gradually reduce the amount you are using before stopping it completely. This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, such as abdominal or stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or trouble with sleeping.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You or your child may need to stop using this medicine several days before having surgery.

Using this medicine while you are pregnant may cause serious unwanted effects in your newborn baby. Tell your doctor right away if you think you are pregnant or if you plan to become pregnant while using this medicine.

Tell your doctor if you smoke tobacco. Smoking may change how well this medicine works.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

APAP/Pentazocine HCl Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Back, leg, or stomach pains


• black, tarry stools


• bleeding gums


• blistering, peeling, or loosening of the skin


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• chest pain


• chills


• cough or hoarseness


• dark urine


• decrease in the frequency of urination


• decrease in urine volume


• diarrhea


• difficult or troubled breathing


• difficulty in passing urine (dribbling)


• difficulty with swallowing


• dizziness


• fast heartbeat


• fever


• fever with or without chills


• general body swelling


• general feeling of tiredness or weakness


• headache


• hives


• irregular, fast or slow, or shallow breathing


• itching


• joint or muscle pain


• loss of appetite


• lower back or side pain


• nausea or vomiting


• nosebleeds


• painful or difficult urination


• pale or blue lips, fingernails, or skin


• pale skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• red skin lesions, often with a purple center


• red, irritated eyes


• shakiness in the legs, arms, hands, or feet


• shortness of breath


• skin rash


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• swelling or puffiness of the face


• swollen glands


• tightness in the chest


• trembling or shaking of the hands or feet


• unusual bleeding or bruising


• unusual tiredness or weakness


• wheezing


• yellowing of the eyes or skin

Incidence not known

• Blood in the urine


• bloody nose


• fainting


• fast, pounding, or irregular heartbeat or pulse


• feeling of warmth


• heavier menstrual periods


• pinpoint red spots on the skin


• redness of the face, neck, arms, and occasionally, upper chest


• sweating

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Abdominal or stomach pain or tenderness


• bleeding gums


• bloody or cloudy urine


• blurred vision


• clay-colored stools


• cold sweats


• confusion


• cool, pale skin


• decreased appetite


• depression


• drowsiness


• fear or nervousness


• increased hunger


• muscle tremors


• nightmares


• rapid, deep breathing


• restlessness


• seeing, hearing, or feeling things that are not there


• seizures


• slurred speech


• stomach cramps


• strange thoughts


• sudden decrease in the amount of urine


• sugar in the urine


• swelling of the feet or lower legs


• unpleasant breath odor


• unusual bleeding or bruising


• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness


• vomiting of blood


• weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

• Continuing ringing or buzzing or other unexplained noise in the ears


• excitement


• hearing loss


• hives or welts


• irritability


• redness of the skin

Incidence not known

• Confusion about identity, place, and time


• constipation


• difficulty in focusing the eyes


• disturbed dreams


• drowsiness


• false or unusual sense of well-being


• relaxed and calm feeling


• sleepiness


• sleeplessness


• trouble sleeping


• unable to sleep


• weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: APAP/Pentazocine HCl side effects (in more detail)

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More APAP/Pentazocine HCl resources

• APAP/Pentazocine HCl Side Effects (in more detail)
• APAP/Pentazocine HCl Use in Pregnancy & Breastfeeding
• Drug Images
• APAP/Pentazocine HCl Drug Interactions
• APAP/Pentazocine HCl Support Group
• 1 Review for APAP/Pentazocine HCl - Add your own review/rating

Compare APAP/Pentazocine HCl with other medications

• Pain

Lioresal

Generic Name: baclofen (Oral route)

BAK-loe-fen

Commonly used brand name(s)

In Canada

• Lioresal


• Lioresal Double Strength

Available Dosage Forms:

• Tablet

Therapeutic Class: Skeletal Muscle Relaxant, Centrally Acting

Chemical Class: Gamma Aminobutyric Acid (class)

Uses For Lioresal

Baclofen is used to help relax certain muscles in your body. It relieves the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis or certain injuries to the spine. Baclofen does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition.

Baclofen acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine's side effects. Baclofen may also be used to relieve other conditions as determined by your doctor.

This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, baclofen is used in certain patients with trigeminal neuralgia (severe burning or stabbing pain along the nerves in the face); also called ''tic douloureux.''

Before Using Lioresal

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of baclofen in children with use in other age groups.

Geriatric

Side effects such as hallucinations, confusion or mental depression, other mood or mental changes, and severe drowsiness may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of baclofen.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Type 2 diabetes mellitus—Baclofen may raise blood sugar levels

• Epilepsy or


• Kidney disease or


• Mental or emotional problems or


• Stroke or other brain disease—The chance of side effects may be increased

Proper Use of baclofen

This section provides information on the proper use of a number of products that contain baclofen. It may not be specific to Lioresal. Please read with care.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For muscle relaxation:
    
    • Adults and teenagers—At first, the dose is 5 milligrams (mg) three times a day. Then, each dose may be increased by 5 mg every three days until the desired response is reached. No more than 80 mg should be taken within a twenty-four-hour period.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Lioresal

Do not suddenly stop taking this medicine. Unwanted effects may occur if the medicine is stopped suddenly. Check with your doctor for the best way to reduce gradually the amount you are taking before stopping completely.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; other muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using baclofen.

This medicine may cause drowsiness, dizziness, vision problems, or clumsiness or unsteadiness in some people. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert, well-coordinated, and able to see well.

For diabetic patients:

• This medicine may cause your blood sugar levels to rise. If you notice a change in the results of your blood or urine sugar test or if you have any questions about this, check with your doctor.

Lioresal Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

• Bloody or dark urine


• chest pain


• fainting


• hallucinations (seeing or hearing things that are not there)


• mental depression or other mood changes


• ringing or buzzing in the ears


• skin rash or itching

Symptoms of overdose

• Blurred or double vision


• convulsions (seizures)


• muscle weakness (severe)


• shortness of breath or unusually slow or troubled breathing


• vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Confusion


• dizziness or lightheadedness


• drowsiness


• nausea


• unusual weakness, especially muscle weakness

Less common or rare

• Abdominal or stomach pain or discomfort


• clumsiness, unsteadiness, trembling, or other problems with muscle control


• constipation


• diarrhea


• difficult or painful urination or decrease in amount of urine


• false sense of well-being


• frequent urge to urinate or uncontrolled urination


• headache


• loss of appetite


• low blood pressure


• muscle or joint pain


• numbness or tingling in hands or feet


• pounding heartbeat


• sexual problems in males


• slurred speech or other speech problems


• stuffy nose


• swelling of ankles


• trouble in sleeping


• unexplained muscle stiffness


• unusual excitement


• unusual tiredness


• weight gain

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

• Convulsions (seizures)


• hallucinations (seeing or hearing things that are not there)


• increase in muscle spasm, cramping, or tightness


• mood or mental changes


• unusual nervousness or restlessness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Lioresal side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Lioresal resources

• Lioresal Side Effects (in more detail)
• Lioresal Dosage
• Lioresal Use in Pregnancy & Breastfeeding
• Drug Images
• Lioresal Drug Interactions
• Lioresal Support Group
• 5 Reviews for Lioresal - Add your own review/rating

• Lioresal Prescribing Information (FDA)


• Lioresal Monograph (AHFS DI)


• Lioresal MedFacts Consumer Leaflet (Wolters Kluwer)


• Baclofen Prescribing Information (FDA)


• Baclofen Professional Patient Advice (Wolters Kluwer)


• Gablofen Prescribing Information (FDA)


• Gablofen Consumer Overview


• Lioresal Intrathecal Prescribing Information (FDA)

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Angina Pectoris Prophylaxis Medications

Drugs associated with Angina Pectoris Prophylaxis

The following drugs and medications are in some way related to, or used in the treatment of Angina Pectoris Prophylaxis. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Learn more about Angina Pectoris Prophylaxis

Medical Encyclopedia:

• Angina

Drug List:

Adalat

Arthritis-Pain

Arthritis-Pain-Formula

Ascriptin

Ascriptin-Maximum-Strength

Aspergum-Gum

Aspir-81

Aspir-Low

Aspirin-Buffered

Aspirin-Lite-Coat

Aspirin-Low-Dose

Aspiritab

Bayer

Bayer-Plus

Bayer-Low-Adult-Strength-Controlled-Release-Tablets

Bayer-Aspirin-With-Calcium

Buffered-Aspirin

Bufferin

Bufferin-Arthritis-Strength

Bufferin-Extra-Strength

Cardene

Cardene-Iv

Cardene-Sr-Sustained-Release-Capsules

Cardizem

Cardizem-Cd-24-Hour-Sustained-Release-Beads-Capsules

Cardizem-La-24-Hour-Extended-Release-Beads-Tablets

Cartia-Xt-24-Hour-Sustained-Release-Beads-Capsules

Dilacor-Xr-24-Hour-Sustained-Release-Capsules

Dilatrate-Sr

Dilt-Xr-24-Hour-Sustained-Release-Capsules

Diltia-Xt-24-Hour-Sustained-Release-Capsules

Diltiazem-Hydrochloride-Cd

Diltiazem-Hydrochloride-Sr

Diltiazem-Hydrochloride-Xr

Diltiazem-Hydrochloride-Xt

Diltzac

Dynacirc

Dynacirc-Cr-Extended-Release-Tablets

Easprin

Ecotrin-Delayed-Release-Tablets

Ecotrin-Adult-Low-Strength

Ecotrin-Maximum-Strength

Empirin

Fasprin

Genacote

Halfprin

Imdur

Ismo

Isochron

Isoditrate

Isordil

Isordil-Titradose

Kerlone

Levatol

Litecoat-Aspirin

Lopressor

Matzim-La

Medi-Seltzer-Effervescent-Tablets

Metoprolol-Succinate-Er

Minitran-Patch

Monoket

Nitrek-Transdermal

Nitro-Td-Patch-A-Transdermal

Nitro-Bid-Ointment

Nitro-Dur-Patch

Nitro-Time-Controlled-Release-Capsules

Nitrocot

Nitrogard

Nitrol-Appli-Kit-Topical

Nitrolingual-Pumpspray-Spray

Nitromist

Nitroquick

Nitrostat

Norwich-Aspirin

Plendil

Procardia

St-Joseph-Aspirin-Adult-Ec

St-Joseph-Aspirin-Adult-Chewable

St-Joseph-81-Mg-Adult-Chewable-Tablets

Stanback-Analgesic

Sular-Extended-Release-Tablets

Taztia-Xt-24-Hour-Extended-Release-Beads-Capsules

Tenormin

Tiazac

Toprol

Transderm-Nitro

Tri-Buffered-Aspirin

Vascor

Ysp-Aspirin

Zebeta

Zorprin-Controlled-Release-Tablets

Cordarone IV

Generic Name: amiodarone (Oral route)

a-mee-OH-da-rone

Oral route(Tablet)

Amiodarone has several potentially fatal toxicities, the most important of which is pulmonary toxicity (hypersensitivity pneumonitis or interstitial/alveolar pneumonitis). Liver injury is common, but is usually mild and evidenced only by abnormal liver enzymes. Overt liver disease can occur, however, and has been fatal in a few cases. Amiodarone can exacerbate the arrhythmia, e.g., by making the arrhythmia less well tolerated or more difficult to reverse. Patients with the indicated arrhythmias must be hospitalized while the loading dose is given, and a response generally requires at least one week, usually two or more .

Commonly used brand name(s)

In the U.S.

• Cordarone


• Pacerone

Available Dosage Forms:

• Tablet

Therapeutic Class: Antiarrhythmic, Group III

Chemical Class: Benzofuran

Uses For Cordarone IV

Amiodarone is used to treat life-threatening heart rhythm problems called ventricular arrhythmias. This medicine is used in patients who have already been treated with other medicines that did not work.

Amiodarone belongs to the group of medicines known as antiarrhythmics. It works directly on the heart tissue and will slow the nerve impulses in the heart. This helps keep the heart rhythm normal.

This medicine is available only with your doctor's prescription.

Before Using Cordarone IV

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of amiodarone in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amiodarone in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving amiodarone.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Bepridil


• Cisapride


• Dronedarone


• Grepafloxacin


• Indinavir


• Levomethadyl


• Mesoridazine


• Nelfinavir


• Pimozide


• Posaconazole


• Ritonavir


• Saquinavir


• Sparfloxacin


• Terfenadine


• Thioridazine


• Tipranavir


• Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Acecainide


• Alprenolol


• Amiodarone


• Amisulpride


• Amitriptyline


• Amlodipine


• Amoxapine


• Amprenavir


• Apomorphine


• Aprindine


• Arsenic Trioxide


• Asenapine


• Astemizole


• Atazanavir


• Atenolol


• Azimilide


• Azithromycin


• Betaxolol


• Bevantolol


• Bisoprolol


• Boceprevir


• Bretylium


• Bucindolol


• Carteolol


• Carvedilol


• Celiprolol


• Chloral Hydrate


• Chloroquine


• Chlorpromazine


• Ciprofloxacin


• Citalopram


• Clarithromycin


• Clomipramine


• Clozapine


• Crizotinib


• Darunavir


• Dasatinib


• Delavirdine


• Desipramine


• Dibenzepin


• Digoxin


• Dilevalol


• Diltiazem


• Disopyramide


• Dofetilide


• Dolasetron


• Doxepin


• Droperidol


• Eletriptan


• Enflurane


• Erythromycin


• Esmolol


• Etravirine


• Felodipine


• Fentanyl


• Fingolimod


• Flecainide


• Fluconazole


• Flunarizine


• Fluoxetine


• Fosamprenavir


• Foscarnet


• Gallopamil


• Gatifloxacin


• Gemifloxacin


• Granisetron


• Halofantrine


• Haloperidol


• Halothane


• Ibutilide


• Iloperidone


• Imipramine


• Iohexol


• Isoflurane


• Isradipine


• Itraconazole


• Ketoconazole


• Labetalol


• Lacidipine


• Lapatinib


• Lercanidipine


• Levobunolol


• Levofloxacin


• Lidocaine


• Lidoflazine


• Lopinavir


• Loratadine


• Lorcainide


• Lovastatin


• Lumefantrine


• Manidipine


• Mefloquine


• Mepindolol


• Methadone


• Metipranolol


• Metoprolol


• Metronidazole


• Mibefradil


• Moricizine


• Moxifloxacin


• Nadolol


• Nebivolol


• Nicardipine


• Nifedipine


• Nilotinib


• Nilvadipine


• Nimodipine


• Nisoldipine


• Nitrendipine


• Norfloxacin


• Nortriptyline


• Octreotide


• Ofloxacin


• Ondansetron


• Oxprenolol


• Paliperidone


• Pazopanib


• Penbutolol


• Pentamidine


• Perflutren Lipid Microsphere


• Perhexiline


• Pindolol


• Pranidipine


• Prilocaine


• Probucol


• Prochlorperazine


• Promethazine


• Propafenone


• Propranolol


• Protriptyline


• Quetiapine


• Quinidine


• Quinine


• Ranolazine


• Rifampin


• Risperidone


• Salmeterol


• Sematilide


• Sertindole


• Simvastatin


• Sirolimus


• Sodium Phosphate


• Sodium Phosphate, Dibasic


• Sodium Phosphate, Monobasic


• Solifenacin


• Sorafenib


• Sotalol


• Spiramycin


• St John's Wort


• Sulfamethoxazole


• Sultopride


• Sunitinib


• Tacrolimus


• Talinolol


• Tedisamil


• Telaprevir


• Telithromycin


• Tertatolol


• Tetrabenazine


• Timolol


• Tizanidine


• Toremifene


• Trazodone


• Trifluoperazine


• Trimethoprim


• Trimipramine


• Vandetanib


• Vardenafil


• Vasopressin


• Vemurafenib


• Verapamil


• Voriconazole


• Warfarin


• Ziprasidone


• Zolmitriptan


• Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abarelix


• Acenocoumarol


• Aprindine


• Cholestyramine


• Clonazepam


• Clopidogrel


• Cyclosporine


• Dicumarol


• Digitoxin


• Flecainide


• Fosphenytoin


• Methotrexate


• Nevirapine


• Phenytoin


• Procainamide


• Rifapentine


• Rosuvastatin


• Theophylline


• Tolterodine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• AV block (type of abnormal heart rhythm), with no pacemaker or


• Bradycardia (slow heartbeat) or


• Cardiogenic shock or


• Sick sinus syndrome (type of abnormal heart rhythm), with no pacemaker—Should not be used in patients with these conditions.

• Eye or vision problems or


• Heart disease (e.g., congestive heart failure) or


• Heart rhythm problems (e.g., QT prolongation) or


• Hypokalemia (low potassium in the blood) or


• Hypomagnesemia (low magnesium in the blood) or


• Hypotension (low blood pressure) or


• Lung disease or other breathing problems (e.g., interstitial pneumonitis) or


• Thyroid problems—Use with caution. May make these conditions worse.

Proper Use of amiodarone

This section provides information on the proper use of a number of products that contain amiodarone. It may not be specific to Cordarone IV. Please read with care.

You will receive your first dose of this medicine in a hospital. Your doctor will watch you closely after you take this medicine to make sure you do not have any serious side effects.

Take amiodarone exactly as directed by your doctor even though you may feel well. Do not take more medicine than your doctor ordered and do not miss any doses. It may take one or two weeks before your body responds to this medicine.

This medicine should come with a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

You may take this medicine with or without food, but take amiodarone the same way each time.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For ventricular arrhythmias:
    
    • Adults—At first, 800 to 1600 milligrams (mg) per day taken in divided doses. Your doctor may adjust your dose as needed and tolerated.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Cordarone IV

It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Tell your doctor right away if you are having shortness of breath, chest tightness, wheezing, or any type of breathing problem while using this medicine.

This medicine can cause changes in your heart rhythm, such as a condition called QT prolongation. It may cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

Liver problems may occur while you are using this medicine. Stop using this medicine and check with your doctor right away if you are having more than one of these symptoms: abdominal pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.

You may need to carry a medical identification card or bracelet showing that you are taking this medicine. Ask your doctor about this.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

Amiodarone increases the sensitivity of your skin to sunlight; too much sun exposure could cause a serious sunburn. Your skin may continue to be sensitive to sunlight for several months after treatment is stopped. Use a sunscreen when you are outdoors. Wear protective clothing and hats. Avoid sunlamps and tanning beds.

After you have taken this medicine for a long time, it may cause a blue-gray color to appear on your skin, especially in areas exposed to the sun, such as your face, neck, and arms. This color will usually fade after treatment with amiodarone has ended, although it may take several months. Check with your doctor if this color change occurs.

Grapefruits and grapefruit juice may increase the side effects from amiodarone by increasing the amount of this medicine in your body. You should not eat grapefruit or drink grapefruit juice while you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e.g., St. John's wort) or vitamin supplements.

Cordarone IV Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Cough


• dizziness, lightheadedness, or fainting


• fever (slight)


• numbness or tingling in the fingers or toes


• painful breathing


• sensitivity of the skin to sunlight


• shortness of breath


• trembling or shaking of the hands


• trouble with walking


• unusual and uncontrolled movements of the body


• weakness of the arms or legs

Less common

• Blue-gray coloring of the skin on the face, neck, and arms


• blurred vision or blue-green halos seen around objects


• coldness


• dry eyes


• dry, puffy skin


• fast or irregular heartbeat


• nervousness


• pain and swelling in the scrotum


• sensitivity of the eyes to light


• sensitivity to heat


• slow heartbeat


• sweating


• swelling of the feet or lower legs


• trouble with sleeping


• unusual tiredness


• weight gain or loss

Rare

• Skin rash


• yellow eyes or skin

Incidence not known

• Abdominal or stomach pain


• agitation


• back, leg, or stomach pains


• bleeding gums


• blistering, peeling, or loosening of the skin


• bloating


• blood in the urine


• bloody, black, or tarry stools


• blue lips, fingernails, or skin


• blurred or double vision


• chest pain


• chills


• clay-colored stools


• coma


• confusion


• confusion as to time, place, or person


• coughing or spitting up blood


• cracks in the skin


• dark urine


• decreased urine output


• depression


• diarrhea


• difficult or labored breathing


• difficult urination


• dry cough


• eye pain


• fast heartbeat


• fatigue


• general body swelling


• high fever


• holding false beliefs that cannot be change by fact


• hostility


• inability to have or keep an erection


• indigestion


• irregular, fast or slow, or shallow breathing


• irritability


• itching


• joint or muscle pain


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• lethargy


• loss in sexual ability, desire, drive, or performance


• loss of heat from the body


• lower back or side pain


• mood or mental change


• muscle cramps or spasms


• muscle pain or stiffness


• muscle twitching


• no breathing


• noisy breathing


• nosebleeds


• pain in the abdomen, groin, or scrotum


• pain or burning with urination


• pains in the stomach, side, or abdomen, possibly radiating to the back


• pale skin


• pinpoint red spots on the skin


• rapid weight gain


• rash


• red skin lesions, often with a purple center


• red, irritated eyes


• red, swollen skin


• scaly skin


• seeing, hearing, or feeling things that are not there


• seizures


• severe headache


• sneezing


• sore throat


• sores, ulcers, or white spots on the lips or in mouth


• stupor


• swelling of the face, ankles, or hands


• swelling of the scrotum


• swollen or painful glands


• tightness in the chest


• troubled breathing


• unpleasant breath odor


• unusual bleeding or bruising


• unusual excitement, nervousness, or restlessness


• unusual tiredness or weakness


• vomiting of blood


• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Constipation


• headache


• loss of appetite


• nausea and vomiting

Less common

• Bitter or metallic taste


• decrease in sexual interest


• decreased sexual ability in males


• dizziness


• flushing of the face

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Cordarone IV side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Cordarone IV resources

• Cordarone IV Side Effects (in more detail)
• Cordarone IV Use in Pregnancy & Breastfeeding
• Cordarone IV Drug Interactions
• Cordarone IV Support Group
• 0 Reviews for Cordarone IV - Add your own review/rating

Compare Cordarone IV with other medications

• Arrhythmia
• Supraventricular Tachycardia
• Ventricular Fibrillation
• Ventricular Tachycardia

Vancomycin Capsules

Pronunciation: VAN-koe-MYE-sin
Generic Name: Vancomycin
Brand Name: Vancocin

Vancomycin Capsules is used for:

Treating certain bacterial infections of the stomach or bowel.

Vancomycin Capsules is an antibiotic. It works by killing sensitive bacteria.

Do NOT use Vancomycin Capsules if:

• you are allergic to any ingredient in Vancomycin Capsules

Contact your doctor or health care provider right away if any of these apply to you.

Before using Vancomycin Capsules:

Some medical conditions may interact with Vancomycin Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have kidney problems, colitis or other inflammation of the bowel, or hearing problems

Some MEDICINES MAY INTERACT with Vancomycin Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aminoglycosides (eg, tobramycin) because the risk of kidney problems or hearing problems may be increased


• Methotrexate because the risk of its side effects may be increased by Vancomycin Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Vancomycin Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Vancomycin Capsules:

Use Vancomycin Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Vancomycin Capsules by mouth with or without food.


• To clear up your infection completely, take Vancomycin Capsules for the full course of treatment. Keep taking it even if you feel better in a few days.


• Continue to use Vancomycin Capsules even if you feel well. Do not miss any doses.


• If you miss a dose of Vancomycin Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Vancomycin Capsules.

Important safety information:

• Vancomycin Capsules only works against bacteria; it does not treat viral infections (eg, the common cold).


• Long-term or repeated use of Vancomycin Capsules may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• Be sure to use Vancomycin Capsules for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Kidney problems, including reports of kidney failure, have occurred in patients taking Vancomycin Capsules. These kidney problems can occur either during treatment or after treatment is stopped, although they have typically occurred within 1 week after Vancomycin Capsules has been stopped. Contact your doctor right away if you experience decreased urination.


• Lab tests, including kidney function tests and hearing tests, may be performed while you use Vancomycin Capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Vancomycin Capsules with caution in the ELDERLY; they may be more sensitive to its effects.


• Vancomycin Capsules should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is not known if Vancomycin Capsules can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Vancomycin Capsules while you are pregnant. Vancomycin Capsules is found in breast milk. Do not breast-feed while taking Vancomycin Capsules.

Possible side effects of Vancomycin Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; gas; headache; nausea; stomach pain; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; decreased, difficult, or painful urination; fainting; fever, chills, or sore throat; flushing; red, swollen, or blistered skin; ringing in the ears, hearing loss, or other hearing changes; severe or persistent diarrhea; severe or persistent dizziness or light-headedness; shortness of breath; swelling of the hands, ankles, or feet; symptoms of low blood potassium levels (eg, irregular heartbeat; muscle pain, weakness, or cramping); unusual bruising or bleeding; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Vancomycin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Vancomycin Capsules:

Store Vancomycin Capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Vancomycin Capsules out of the reach of children and away from pets.

General information:

• If you have any questions about Vancomycin Capsules, please talk with your doctor, pharmacist, or other health care provider.


• Vancomycin Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Vancomycin Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Vancomycin resources

• Vancomycin Side Effects (in more detail)
• Vancomycin Dosage
• Vancomycin Use in Pregnancy & Breastfeeding
• Vancomycin Drug Interactions
• Vancomycin Support Group
• 13 Reviews for Vancomycin - Add your own review/rating

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• Burns, External
• Clostridial Infection
• Endocarditis
• Enterocolitis
• Febrile Neutropenia
• Meningitis
• Methicillin-Resistant Staphylococcus Aureus Infection
• Nosocomial Pneumonia
• Peritonitis
• Pneumonia
• Prevention of Perinatal Group B Streptococcal Disease
• Pseudomembranous Colitis
• Sepsis
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• Skin Infection
• Surgical Prophylaxis

Vaginal preparations

Vaginal preparations are products, which are applied or inserted in the vagina to treat vaginal conditions. They may contain antibacterial or antifungal agents to treat infection, or they have agents such as hormones that relieve menopausal symptoms. Vaginal preparations are available as creams, pessaries (tablet), gels or rings.

See also

• miscellaneous vaginal agents
• vaginal anti-infectives

Drug List:

Safyral

Generic Name: drospirenone, ethinyl estradiol, and levomefolate (Oral route)

droe-SPYE-re-none, ETH-i-nil es-tra-DYE-ol, lee-voe-me-FOE-late KAL-see-um, lee-voe-me-FOE-late KAL-see-um

Oral route(Tablet)

Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptives (COC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, COCs should not be used by women who are over 35 years of age and smoke .

Commonly used brand name(s)

In the U.S.

• Beyaz


• Safyral

Available Dosage Forms:

• Tablet

Uses For Safyral

Drospirenone, ethinyl estradiol, and levomefolate combination is used to prevent pregnancy. It is a birth control pill that contains two types of hormones, ethinyl estradiol and drospirenone, and when taken properly, prevents pregnancy. It works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization is prevented.

This medicine is also used to treat premenstrual dysphoric disorder (PMDD) and acne in women at least 14 years of age. PMDD is a severe form of premenstrual syndrome (PMS). Patients with PMDD may have severe emotional and physical symptoms a few days before their menstrual flow starts.

This medicine also contains levomefolate, which is a form of folic acid. Folic acid is one of the B vitamins that pregnant women need to help prevent neural tube defects in a baby.

No contraceptive method is 100 percent effective. Birth control methods such as having surgery to become sterile or not having sex are more effective than birth control pills. Discuss your options for birth control with your doctor.

This medicine does not prevent AIDS or other sexually transmitted diseases. It will not help as emergency contraception, such as after unprotected sexual contact.

This medicine is available only with your doctor's prescription.

Before Using Safyral

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies on the relationship of age to the effects of drospirenone, ethinyl estradiol, and levomefolate combination have not been performed in the pediatric population. However, pediatric-specific problems that would limit the usefulness of this medication in teenagers are not expected. This medicine may be used for birth control in teenage females but should not be used before the start of menstruation.

Geriatric

Appropriate studies on the relationship of age to the effects of drospirenone, ethinyl estradiol, and levomefolate combination have not been performed in the geriatric population. This medicine should not be used in elderly women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Boceprevir

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Boceprevir


• Felbamate


• Isotretinoin


• Paclitaxel


• Paclitaxel Protein-Bound


• Theophylline


• Tizanidine


• Tranexamic Acid

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alprazolam


• Amoxicillin


• Ampicillin


• Amprenavir


• Aprepitant


• Atazanavir


• Bacampicillin


• Betamethasone


• Bexarotene


• Bosentan


• Carbamazepine


• Colesevelam


• Cyclosporine


• Darunavir


• Delavirdine


• Doxycycline


• Efavirenz


• Etravirine


• Fosamprenavir


• Fosaprepitant


• Fosphenytoin


• Ginseng


• Griseofulvin


• Lamotrigine


• Licorice


• Minocycline


• Modafinil


• Mycophenolate Mofetil


• Mycophenolic Acid


• Nelfinavir


• Nevirapine


• Oxcarbazepine


• Oxytetracycline


• Phenobarbital


• Phenytoin


• Pioglitazone


• Prednisolone


• Primidone


• Rifabutin


• Rifampin


• Rifapentine


• Ritonavir


• Roflumilast


• Rosuvastatin


• Rufinamide


• Selegiline


• St John's Wort


• Telaprevir


• Tetracycline


• Tipranavir


• Topiramate


• Troglitazone


• Troleandomycin


• Valdecoxib


• Voriconazole


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Caffeine


• Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Abnormal or unusual vaginal bleeding or


• Adrenal disease or


• Blood clots, or history of or


• Breast cancer, active or history of or


• Diabetes with kidney, eye, nerve, or blood vessel damage or


• Heart attack, history of or


• Heart or blood vessel disease or


• Heart rhythm problems or


• Hypertension (high blood pressure), uncontrolled or


• Kidney disease or


• Liver disease, including tumors or cancer or


• Migraine headache, new or worse or a new kind of headache or


• Problems with circulation or blood clots, now or in the past or


• Problems with heart valves or


• Stroke, history of—Should not be used in patients with these conditions.

• Angioedema (swelling of the face, tongue, or throat), inherited or


• Chloasma gravidarum (skin disorder during pregnancy), history of or


• Cholestasis (bile problem) during pregnancy, history of or


• Depression, history of or


• Diabetes or


• Dyslipidemia (high cholesterol or fats in the blood), uncontrolled or


• Gallbladder disease or


• Hyperkalemia (high potassium in the blood) or


• Hypertension (high blood pressure), controlled—Use with caution. May make these conditions worse.

Proper Use of drospirenone, ethinyl estradiol, and levomefolate

This section provides information on the proper use of a number of products that contain drospirenone, ethinyl estradiol, and levomefolate. It may not be specific to Safyral. Please read with care.

To make using hormonal contraceptives as safe and reliable as possible, you should understand how and when to use them and what effects may be expected.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

This medicine is available in blister packs. Each blister pack contains 28 tablets with different colors that need to be taken in the same order as directed on the blister pack.

When you begin using this medicine, your body will require at least 7 days to adjust before a pregnancy will be prevented. Use a second form of contraception, such as a condom, spermicide, or diaphragm, for the first 7 days of your first cycle of pills.

Take this medicine at the same time each day, after the evening meal or at bedtime. You may take this medicine with or without food.

Do not skip or delay taking your pill by more than 24 hours. If you miss a dose, you could get pregnant. Ask your doctor for ways to help you remember to take your pills or about using another method of birth control.

You may have light bleeding or spotting when you first take the pill.

You may feel sick or nauseous, especially during the first few months that you take this medicine. If your nausea is continuous and does not go away, call your doctor.

If you vomit or have diarrhea within 3 to 4 hours of taking this medicine, follow the instructions in the patient leaflet or call your doctor.

If you are switching from a combination hormonal method (e.g., another pill, patch, vaginal ring) to using Beyaz® or Safyral™, take this medicine on the first day of your period. If you do not start your period, see your doctor for a pregnancy test. If you have used a vaginal ring or patch, take the pill on the day the ring or patch is removed. You must also use a second method of birth control (e.g., condom, diaphragm, spermicide) for the first 7 days you take this medicine.

If you are switching from a progestin-only method (e.g., progestin-only pill, implant, injection, intrauterine system) to using Beyaz® or Safyral™, take the medicine on the day you would have taken your next progestin-only pill, or on the day your implant or IUD is removed, or on the day you would have your next injection. You must also use a second method of birth control (e.g., condom, diaphragm, spermicide) for the first 7 days you take this medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Your doctor may ask you to begin your dose on the first day of your menstrual period (called Day 1 Start) or on the first Sunday after your menstrual period starts (called Sunday Start). When you begin on a certain day it is important that you follow that schedule, even if you miss a dose. Do not change your schedule on your own. If the schedule that you use is not convenient, check with your doctor about changing it. For a Sunday start, you need to use another form of birth control (e.g., condom, diaphragm, spermicide) for the first 7 days.

• For oral dosage form (tablets):
  
  • For contraception (to prevent pregnancy), PMDD, or acne:
    
    • Adults and teenagers—One tablet taken at the same time each day for 28 days.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

Call your doctor or pharmacist for instructions.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Safyral

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and does not cause unwanted effects. These visits will usually be every 6 to 12 months, but some doctors require them more often.

Although you are using this medicine to prevent pregnancy, you should know that using this medicine while you are pregnant could harm the unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

Vaginal bleeding of various amounts may occur between your regular menstrual periods during the first 3 months of use. This is sometimes called spotting when slight, or breakthrough bleeding when heavier.

• If this should occur, continue with your regular dosing schedule.


• The bleeding usually stops within 1 week. Check with your doctor if the bleeding continues for more than 1 week.


• If bleeding continues after you have been taking hormonal contraceptives on schedule and for more than 3 months, check with your doctor.

Check with your doctor right away if you miss a menstrual period. Missed periods may occur if you skip one or more pink tablets and have not taken your pills exactly as directed. If you miss two periods in a row, talk to your doctor. You might need a pregnancy test.

If you suspect that you may be pregnant, stop using this medicine immediately and check with your doctor. You should continue to take folate supplements.

Do not use this medicine if you smoke cigarettes or if you are over 35 years old. If you smoke while using birth control pills, you increase your risk of having a heart attack, stroke, or blood clot. Your risk is even higher if you are over age 35, if you have diabetes, high blood pressure, high cholesterol, or if you are overweight. Talk with your doctor about ways to stop smoking. Keep your diabetes under control. Ask your doctor about diet and exercise to control your weight and blood cholesterol level.

Stop using this medicine and check with your doctor right away if you have pain in the chest, groin, or legs, especially the calves; difficulty with breathing; a sudden, severe headache; slurred speech; a sudden, unexplained shortness of breath; a sudden loss of coordination; or vision changes while using this medicine.

Check with your doctor immediately if you have problems wearing contact lenses or if blurred vision, difficulty with reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Stop using this medicine and check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.

Check with your doctor before refilling an old prescription, especially after a pregnancy. You will need another physical examination and your doctor may change your prescription.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or certain medical tests.

This medicine may cause skin discoloration. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e.g., St. John's wort) or vitamin supplements.

Safyral Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Breast pain or tenderness


• headache, severe and throbbing


• heavy nonmenstrual vaginal bleeding


• irregular menstrual periods


• nausea


• normal menstrual bleeding occurring earlier, possibly lasting longer than expected

Less common

• Longer or heavier menstrual periods


• unusual tiredness or weakness


• vomiting

Incidence not known

• Abdominal or stomach pain


• chills


• clay-colored stools


• dark urine


• difficulty with breathing


• dizziness


• fever


• headache


• itching


• loss of appetite


• pain in the chest, groin, or legs, especially the calves


• rash


• slurred speech


• sudden loss of coordination


• sudden, severe weakness or numbness in the arm or leg


• sudden, unexplained shortness of breath


• unpleasant breath odor


• unusual tiredness or weakness


• vision changes


• vomiting of blood


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Crying


• decreased interest in sexual intercourse


• delusions of persecution, mistrust, suspiciousness, and/or combativeness


• false or unusual sense of well-being


• inability to have or keep an erection


• irritability


• loss in sexual ability, desire, drive, or performance


• mental depression


• quick to react or overreact emotionally


• rapidly changing moods


• weight gain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Safyral side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Safyral resources

• Safyral Side Effects (in more detail)
• Safyral Use in Pregnancy & Breastfeeding
• Safyral Drug Interactions
• Safyral Support Group
• 25 Reviews for Safyral - Add your own review/rating

• Safyral MedFacts Consumer Leaflet (Wolters Kluwer)


• Safyral Prescribing Information (FDA)


• Safyral Consumer Overview


• Beyaz Prescribing Information (FDA)


• Beyaz MedFacts Consumer Leaflet (Wolters Kluwer)


• Beyaz Consumer Overview

Compare Safyral with other medications

• Birth Control