Senna Laxative Tablets or Boots Natural Senna Laxative Tablets

1. Name Of The Medicinal Product

Boots Natural Senna Laxative Tablets

2. Qualitative And Quantitative Composition

Active ingredient	mg/tablet
Sennosides, obtained from Alexandrian Senna Fruit	7.5

3. Pharmaceutical Form

Tablet

4. Clinical Particulars

4.1 Therapeutic Indications

For the relief of occasional constipation.

4.2 Posology And Method Of Administration

Adults and children over 12 years: 2 tablets

Children 6-12 years: 1 tablet

Children under 6 years: Not recommended

Elderly: The normal adult dose is suitable in the elderly.

The tablets should preferably be taken at bedtime and the dose should be decreased as the bowel habit becomes regular.

For oral administration.

4.3 Contraindications

Hypersensitivity to any of the ingredients. This product should not be used when abdominal pain, intestinal obstruction, nausea or vomiting is present.

4.4 Special Warnings And Precautions For Use

This product should not be used for prolonged periods since they may decrease the sensitivity of the intestinal mucous membranes, so larger doses have to be taken and the bowel fails to respond to normal stimuli.

Laxatives should not be taken where there is severe abdominal pain or used regularly for prolonged periods, except on medical advice.

Keep all medicines out of the reach of children.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

No clinically significant drug interactions known.

4.6 Pregnancy And Lactation

The safety of this product taken during pregnancy and lactation has not been established but use during these periods is not considered to constitute a hazard.

4.7 Effects On Ability To Drive And Use Machines

No adverse effects known.

4.8 Undesirable Effects

Prolonged use may produce watery diarrhoea with excessive loss of fluid and electrolytes, particularly potassium, muscular weakness and weight loss. Changes in the intestinal musculature associated with malabsorption and dilation of the bowel, similar to ulcerative colitis and to megacolon, may also occur. Cardiac and renal symptoms have been reported. Melanosis coli and a red or yellow discolouration of the urine and faeces may also occur.

4.9 Overdose

Overdosage may produce watery diarrhoea with excessive loss of water and electrolytes, particularly potassium. Treatment consists of emptying the stomach by emesis or aspiration and lavage. Otherwise treatment should include symptomatic and supportive measures, particularly replacement of fluid and electrolyte losses.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Senna is an anthraquinone laxative. The stimulant effect of senna occurs in the colon, whilst the stomach and small intestine are not normally affected.

5.2 Pharmacokinetic Properties

There is some absorption of anthraquinone laxatives following administration by mouth.

Senna glycosides are hydrolysed by colonic bacteria in the intestinal tract and the active anthraquinones liberated into the colon.

Excretion occurs in the urine and the faeces and also in other secretions including breast milk.

5.3 Preclinical Safety Data

There are no preclinical data of relevance to the prescriber which are additional to that already included.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Tricalcium phosphate 118

Magnesium stearate

Maize starch

Purified water

6.2 Incompatibilities

None known.

6.3 Shelf Life

Amber glass bottle with unlined polypropylene cap: 18 months

Amber glass bottle with polypropylene cap with IHS liner faced with surlyn/aluminium or polyethylene/aluminium: 24 months

HDPE bottle with polypropylene cap with IHS liner faced with either surlyn/aluminium or polyethylene/aluminium: 24 months

HDPE bottle with polypropylene cap with waxed aluminium faced liner: 24 months

PVC/PVDC/aluminium foil blister: 36 months

6.4 Special Precautions For Storage

Glass bottle: Do not store above 25°C. Store in original package.

Blister: Do not store above 25°C. Store in original package.

PET: None

6.5 Nature And Contents Of Container

1. Amber glass bottle, unlined polypropylene cap

Pack size: 50, 100, 200

2. Amber glass bottle, polypropylene cap with IHS liner faced with surlyn/aluminium or polyethylene/aluminium.

Pack size: 50, 100, 200

3. HDPE bottle with polypropylene cap with IHS liner faced with surlyn/aluminium or polyethylene/aluminium.

Pack size: 50, 100, 200

4. HDPE bottle with polypropylene cap with waxed aluminium faced liner.

Pack size: 50, 100, 200

5. PVC/PVDC aluminium foil blister.

Pack size: 10, 20, 30, 40, 50, 60, 70, 80, 90, 100

6.6 Special Precautions For Disposal And Other Handling

Not applicable.

7. Marketing Authorisation Holder

The Boots Company PLC

1 Thane Road West

Nottingham NG2 3AA

Trading as: BCM

8. Marketing Authorisation Number(S)

PL 0014/5375R

9. Date Of First Authorisation/Renewal Of The Authorisation

Date of grant: 29 August 1984

Date of renewal: 25 September 1996

10. Date Of Revision Of The Text

August 2010

U-cort

hydrocortisone acetate

Dosage Form: cream

Rx only

U-cort Description

The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. Hydrocortisone acetate cream is a member of this class. Hydrocortisone Acetate has the chemical name pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-11β)-. It has the following structural formula:

Molecular Weight: 404.50       Molecular Formula C23H32O6

Each gram of the cream contains 10 mg Hydrocortisone Acetate, USP in a water-washable vanishing cream base containing urea (10%), purified water, stearic acid, propylene glycol, isopropyl myristate, isopropyl palmitate, PPG-26 oleate, sodium laureth sulfate, triethanolamine, xanthan gum, sodium bisulfite, cetyl alcohol, edetate disodium, carbomer 940 with hypoallergenic perfume. It is non-occlusive, and contains no mineral oil, petrolatum, lanolin or parabens.

U-cort - Clinical Pharmacology

Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions.

The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.

Pharmacokinetics

The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses. (See DOSAGE AND ADMINISTRATION.)

Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma protein in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Indications and Usage for U-cort

U-cort (Hydrocortisone Acetate Cream USP, 1%) is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Contraindications

Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.

Warnings

Contains sodium bisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.

Precautions

General

Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.

Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the additions of occlusive dressings.

Therefore, patients receiving a large dose of potent topical steroids applied to a large surface area, or under an occlusive dressing, should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid.

Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug. Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids.

Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity. (See PRECAUTIONS-Pediatric Use.)

If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted. As with any topical corticosteroid product, prolonged use may produce atrophy of the skin and subcutaneous tissues. When used on intertriginous or flexor areas, or on the face, this may occur even with short-term use.

In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.

Information for the Patient

Patients using topical corticosteroids should receive the following information and instructions:

1. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.


2. Patients should be advised not to use this medication for any disorder other than for which it was prescribed.


3. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive unless directed by the physician.


4. Patients should report any signs of local adverse reactions especially under occlusive dressing.


5. Parents of pediatric patients should be advised not to use tight-fitting diapers or plastic pants on a child being treated in the diaper area, as these garments may constitute occlusive dressings.

Laboratory Tests

The following tests may be helpful in evaluating the HPA axis suppression:

 

Urinary free cortisol test

 

ACTH stimulation test

Carcinogenesis, Mutagenesis, and Impairment of Fertility

Long-term animal studies have not been performed to evaluate the carcinogenic potential or the effect on fertility of topical corticosteroids.

Studies to determine mutagenicity with prednisolone and hydrocortisone have revealed negative results.

Pregnancy

Teratogenic Effects

Pregnancy Category C

Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.

Nursing Mothers

It is not known whether topical corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have deleterious effect on the infant. Nevertheless, caution should be exercised when topical corticosteroids are administered to a nursing woman.

Pediatric Use

Pediatric patients may demonstrate greater susceptibility to a topical corticosteroid-induced HPA axis suppression and Cushing's syndrome than mature patients because of a larger skin surface area to body weight ratio.

Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome, and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal suppression in children include linear growth retardation, delayed weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema.

Administration of topical corticosteroids to children should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with the growth and development of children.

Adverse Reactions

The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence beginning with column 1:

Burning	Hypertrichosis
Maceration of the skin	Itching
Acneiform eruptions	Secondary infection
Irritation	Hypopigmentation
Skin atrophy	Dryness
Perioral dermatitis	Striae
Folliculitis	Allergic contact dermatitis
Miliaria

Overdosage

Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects. (See PRECAUTIONS.)

U-cort Dosage and Administration

U-cort (Hydrocortisone Acetate Cream USP, 1%) is generally applied to the affected area as a thin film two to four times daily, depending on the severity of the condition.

Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions.

If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.

How is U-cort Supplied

U-cort® (Hydrocortisone Acetate Cream USP, 1%) is supplied in 5 g (NDC 51672-3009-5) for physician samples,1 oz (28.35 g) (NDC 51672-3009-2), 3 oz (85 g) (NDC 51672-3009-8) and 4.3 oz (123 g) (NDC 51672-3009-4) tube sizes.

Store at controlled room tempertature 15° - 30°C (59°-86°F). Protect from freezing.

Pharmacist: Dispense in tight containers as specified in USP.

Manufactured by:	Taro Pharmaceuticals Inc.
	Brampton, Ontario, Canada L6T 1C1

Distributed by:	TaroPharma
	a division of Taro Pharmaceuticals U.S.A., Inc.
	Hawthorne, NY 10532

U-cort® & TaroPharma® are trademarks of Taro Pharmaceuticals U.S.A., Inc. and/or its affiliates.

Revised: November, 2008

U-cort  hydrocortisone acetate  cream

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 51672-3009 Route of Administration TOPICAL DEA Schedule

INGREDIENTS Name (Active Moiety) Type Strength Hydrocortisone Acetate (Hydrocortisone) Active 10 MILLIGRAM  In 1 GRAM urea Inactive   water Inactive   stearic acid Inactive   propylene glycol Inactive   isopropyl myristate Inactive   isopropyl palmitate Inactive   PPG-26 oleate Inactive   sodium laureth sulfate Inactive   triethanolamine Inactive   xanthan gum Inactive   sodium bisulfite Inactive   cetyl alcohol Inactive   edetate disodium Inactive   carbomer 940 with hypoallergenic perfume Inactive

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 51672-3009-5 5 g (GRAM) In 1 TUBE None 2 51672-3009-2 1 TUBE In 1 CARTON contains a TUBE 2 28.35 g (GRAM) In 1 TUBE This package is contained within the CARTON (51672-3009-2) 3 51672-3009-8 1 TUBE In 1 CARTON contains a TUBE 3 85 g (GRAM) In 1 TUBE This package is contained within the CARTON (51672-3009-8) 4 51672-3009-4 1 TUBE In 1 CARTON contains a TUBE 4 123 g (GRAM) In 1 TUBE This package is contained within the CARTON (51672-3009-4)

Revised: 12/2008Taro Pharmaceuticals U.S.A., Inc.

More U-cort resources

• U-cort Side Effects (in more detail)
• U-cort Use in Pregnancy & Breastfeeding
• U-cort Drug Interactions
• U-cort Support Group
• 0 Reviews for U-cort - Add your own review/rating

• U-cort MedFacts Consumer Leaflet (Wolters Kluwer)


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• Pediaderm HC Lotion MedFacts Consumer Leaflet (Wolters Kluwer)


• ProctoCream-HC Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• U-Cort Concise Consumer Information (Cerner Multum)


• U-Cort Advanced Consumer (Micromedex) - Includes Dosage Information

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Cordran SP

Generic Name: flurandrenolide (Topical application route)

flur-an-DREN-oh-lide

Commonly used brand name(s)

In the U.S.

• Cordran


• Cordran SP


• Cordran Tape

In Canada

• Drenison


• Drenison 1/4


• Drenison Tape

Available Dosage Forms:

• Lotion


• Ointment


• Tape


• Cream

Therapeutic Class: Corticosteroid, Strong

Pharmacologic Class: Adrenal Glucocorticoid

Uses For Cordran SP

Flurandrenolide topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. Flurandrenolide tape is used for dry and scaling skin lesions. This medicine is a corticosteroid (cortisone-like medicine or steroid).

This medicine is available only with your doctor's prescription.

Before Using Cordran SP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of flurandrenolide topical in the pediatric population. However, because of this medicine's toxicity, it should be used with caution. Children may absorb large amounts through the skin, which can cause serious side effects. If your child is using this medicine, follow your doctor's instructions very carefully.

Geriatric

No information is available on the relationship of age to the effects of flurandrenolide topical in geriatric patients.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Cushing's syndrome (adrenal gland disorder) or


• Diabetes or


• Hyperglycemia (high blood sugar) or


• Intracranial hypertension (increased pressure in the head)—Use with caution. May make these conditions worse.

• Infection of the skin at or near the place of application or


• Large sores, broken skin, or severe skin injury at the place of application—The chance of side effects may be increased.

• Moist lesions—Flurandrenolide tape should not be used in patients with these conditions.

Proper Use of flurandrenolide

This section provides information on the proper use of a number of products that contain flurandrenolide. It may not be specific to Cordran SP. Please read with care.

It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.

This medicine is for use on the skin only. Do not get it in your eyes. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.

This medicine should only be used for skin conditions that your doctor is treating. Check with your doctor before using it for other conditions, especially if you think that a skin infection may be present. This medicine should not be used to treat certain kinds of skin infections or conditions, such as severe burns.

Wash your hands with soap and water before and after using this medicine.

Do not use the lotion on the face, groin, or underarms unless directed to do so by your doctor.

Do not use the tape in an area where the skin folds together (e.g. between the fingers).

To use the cream, lotion, or ointment:

• Shake the lotion well before using.


• Apply a thin layer of this medicine to the affected area of the skin. Rub it in gently.


• With the lotion, protect the skin from water, clothing, or anything that causes rubbing until the medicine has dried.


• Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.


• If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.


• If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

To use the tape:

• This medicine comes with patient directions. Read and follow the instructions carefully.


• Gently clean and wash the affected area with soap and water.


• Shave or clip the hair in the affected area to allow good application on the skin and comfortable removal of the tape.


• If you bathe or shower before applying this medicine, make sure that the area to be covered is completely dry.


• Measure and cut the tape to be used on the affected area. Do not tear or break the tape.


• Pull the white paper from the transparent tape. Be careful that the tape does not stick to itself.


• Apply and press the tape gently on the skin.


• Replace the tape every 12 hours, unless otherwise directed by your doctor. Clean and wash the skin. Allow it to dry for 1 hour before applying a new tape.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For redness, itching, and swelling of the skin:
  
  • For topical dosage forms (cream, lotion, and ointment):
    
    • Adults—Apply to the affected area of the skin two or three times per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For topical dosage form (tape):
    
    • Adults—Apply to the affected area of the skin every 12 hours.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Cordran SP

It is very important that your doctor check the progress of you or your child at regular visits for any unwanted effects that may be caused by this medicine. Blood and urine tests may be needed to check for unwanted effects.

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor right away if you or your child have more than one of these symptoms while you are using this medicine: blurred vision; dizziness or fainting; a fast, irregular, or pounding heartbeat; increased thirst or urination; irritability; or unusual tiredness or weakness.

Stop using this medicine and check with your doctor right away if you or your child have a skin rash, burning, stinging, swelling, or irritation on the skin.

Do not use cosmetics or other skin care products on the treated areas.

Cordran SP Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Blistering, burning, crusting, dryness, or flaking of the skin


• irritation


• itching, scaling, severe redness, soreness, or swelling of the skin


• redness and scaling around the mouth


• thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (e.g. between the fingers)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Acne or pimples


• burning and itching of the skin with pinhead-sized red blisters


• burning, itching, and pain in hairy areas, or pus at the root of the hair


• increased hair growth on the forehead, back, arms, and legs


• lightening of normal skin color


• lightening of the treated areas of dark skin


• reddish purple lines on the arms, face, legs, trunk, or groin


• softening of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Cordran SP side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Cordran SP resources

• Cordran SP Side Effects (in more detail)
• Cordran SP Use in Pregnancy & Breastfeeding
• Cordran SP Drug Interactions
• Cordran SP Support Group
• 0 Reviews for Cordran SP - Add your own review/rating

• Cordran SP Concise Consumer Information (Cerner Multum)


• Cordran SP Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Cordran Prescribing Information (FDA)


• Cordran Monograph (AHFS DI)


• Cordran Tape Prescribing Information (FDA)


• Cordran Tape MedFacts Consumer Leaflet (Wolters Kluwer)

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Boots Decongestant Tablets

Boots Decongestant Tablets

(Pseudoephedrine Hydrochloride)

Read all of this leaflet carefully because it contains important information for you.

This medicine is available without prescription to treat minor conditions. However, you still need to take it carefully to get the best results from it.

• Keep this leaflet, you may need to read it again


• Ask your pharmacist if you need more information or advice

What this medicine is for

This medicine contains Pseudoephedrine Hydrochloride, a decongestant, which acts to relieve a blocked nose. It can be used to relieve the symptoms of a blocked nose and blocked sinuses to help you breathe more easily without causing drowsiness.

Before you take this medicine

This medicine can be taken by adults and children aged 12 years and over. However, some people should not take this medicine or should seek the advice of their pharmacist or doctor first.

Do not take:

• 
  If you are allergic to any of the ingredients (see What is in this medicine)


• 
  If you have heart or circulatory problems


• 
  If you have high blood pressure (including that due to a tumour near your kidney)


• 
  If you have diabetes, glaucoma or an overactive thyroid


• 
  If you suffer from severe kidney disease
  


• 
  If you are taking monoamine oxidase inhibitors (for depression), or have taken them within the last 14 days


• 
  If you are taking other medicines containing pseudoephedrine, or other decongestants


• 
  If you are a man with prostate problems


• 
  If you are pregnant
  

Talk to your pharmacist or doctor:

• If you are breastfeeding

If you take other medicines

Before you take these tablets, make sure that you tell your pharmacist about ANY other medicines you might be using at the same time, particularly the following:

• Digoxin (for heart problems)


• Tricyclic antidepressants


• Ergot alkaloids (for migraine)

If you are unsure about interactions with any other medicines, talk to your pharmacist. This includes medicines prescribed by your doctor and medicine you have bought for yourself, including herbal and homeopathic remedies.

How to take this medicine

Check the foil is not broken before use. If it is, do not take that tablet.

Adults and children of 12 years and over


Take one tablet


Every 4 hours, if you need to.
Don't take more than 4 tablets in 24 hours.

Swallow the tablet with water.

Do not give to children under 12 years.

Do not take more than the amount recommended above.

If symptoms do not go away talk to your doctor.

If you take too many tablets: Talk to a doctor straight away. Take your medicine and this leaflet with you.

Possible side effects

Most people will not have problems, but some may get some.

If you get any of these serious side effects, stop taking the tablets. See a doctor at once.

• Difficulty in breathing, swelling of the face, neck, tongue or throat (severe allergic reactions)

These other side effects are less serious. If they bother you talk to your pharmacist or doctor.

• Skin rash


• Feeling sick, being sick, headache, dry mouth


• Fast or irregular heartbeat, high blood pressure


• Restlessness, difficulty sleeping, tremors, anxiety


• Occasionally, difficulty in passing urine (in men)


• Rarely, hallucinations (particularly in children)

If any side effect becomes severe, or you notice any side effect not listed here, please tell your pharmacist or doctor.

How to store this medicine

Keep this medicine in a safe place out of the sight and reach of children, preferably in a locked cupboard.

Use by the date on the end flap of the carton.

What is in this medicine

Each tablet contains Pseudoephedrine Hydrochloride 60 mg, which is the active ingredient.

As well as the active ingredient, the tablets also contain microcrystalline cellulose, maize starch, sodium starch glycolate, pregelatinised maize starch, stearic acid.

The pack contains 12 round white tablets.

Who makes this medicine

Manufactured for the Marketing Authorisation holder

The Boots Company PLC

Nottingham

NG2 3AA

by

Hamol Limited

Nottingham

NG90 2DB

Leaflet prepared June 2008

If you would like any further information about this medicine, please contact

The Boots Company PLC

Nottingham

NG2 3AA

Other formats

To request a copy of this leaflet in Braille, large print or audio please call, free of charge:

0800 198 5000 (UK only)

Please be ready to give the following information:

Product name: Boots Decongestant Tablets

Reference number: PL00014/0375

This is a service provided by the Royal National Institute of the Blind.

BTC31995 vD 28/10/08

Anodesyn Suppositories

1. Name Of The Medicinal Product

Anodesyn Suppositories

Tesco Haemorrhoid Relief Suppositories

Care Haemorrhoid Relief Suppositories

Sainsburys Haemorrhoid Relief Suppositories

Boots Haemorrhoid Relief Suppositories

2. Qualitative And Quantitative Composition

Allantoin	10.25mg
Lidocaine Hydrochloride	10.25mg

For excipients, see 6.1

3. Pharmaceutical Form

Suppositories

White or nearly white suppositories.

4. Clinical Particulars

4.1 Therapeutic Indications

For the symptomatic relief of pain and irritation associated with haemorrhoids.

4.2 Posology And Method Of Administration

Route of administration: For rectal administration.

Adults and the elderly.

If necessary empty the bowels before using the suppository. Remove the protective film and insert the suppository as deep as possible into the rectum. One suppository should be inserted night and morning after each bowel movement. Do not use for more than 7 days unless advised by your doctor.

Children.

Not recommended for children.

4.3 Contraindications

Hypersensitivity to any of the ingredients, especially lidocaine.

4.4 Special Warnings And Precautions For Use

Anodesyn Suppositories/Tesco Haemorrhoid Relief Suppositories / Boots Haemorrhoid Suppositories / Care Haemorrhoid Relief Suppositories/Sainsburys Haemorrhoid Relief Suppositories are intended for use for short periods and should not be used for longer than 7 days without medical advice. Patients should be instructed to seek medical advice if they experience persistent pain or bleeding from the anus, especially where associated with a change in bowel habit, if the stomach is distended or if they are losing weight.

The label will state:

Keep all medicines out of the reach and sight of children.

If symptoms persist for more than 7 days consult your doctor.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

No clinically significant drug interactions known.

4.6 Pregnancy And Lactation

The safety of Anodesyn Suppositories/Tesco Haemorrhoid Relief Suppositories/Boots Haemorrhoid Suppositories /Care Haemorrhoid Relief Suppositories/Sainsburys Haemorrhoid Relief Suppositories in pregnancy and lactation has not been established, but it is thought unlikely to constitute a hazard, though caution should be exercised during the first trimester.

Lidocaine crosses the placenta and is distributed into breast milk..

4.7 Effects On Ability To Drive And Use Machines

No or negligible influence.

4.8 Undesirable Effects

Hypersensitivity to any of the ingredients, particularly lidocaine. Occasionally may cause diarrhoea.

4.9 Overdose

Accidental ingestion may result in anaesthesia of the upper respiratory tract, nausea, vomiting and abdominal discomfort. Ingestion of very large quantities could result in CNS and cardiovascular toxicity.

Treatment should be symptomatic and supportive.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

C05A D0l - Products containing local anaesthetics

Lidocaine has a local anaesthetic action, relieving pain and discomfort in the affected areas. Allantoin is claimed to promote healing.

5.2 Pharmacokinetic Properties

Not applicable

5.3 Preclinical Safety Data

There are no pre-clinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Colloidal Anhydrous Silica

Witepsol W35

Purified Water

6.2 Incompatibilities

Not applicable

6.3 Shelf Life

Three years.

6.4 Special Precautions For Storage

Store at or below 25°C.

6.5 Nature And Contents Of Container

A white polythene lined, unplasticised PVC moulded strip, heat sealed and placed into a printed carton, containing 12 or 24 suppositories.

6.6 Special Precautions For Disposal And Other Handling

None stated.

7. Marketing Authorisation Holder

Thornton & Ross Limited

Linthwaite

Huddersfield

West Yorkshire

HD7 5QH

United Kingdom

8. Marketing Authorisation Number(S)

PL 00240/0071

9. Date Of First Authorisation/Renewal Of The Authorisation

6^th September 2002

10. Date Of Revision Of The Text

14/04/2011

HB-VAX II

1. Name Of The Medicinal Product

HB-VAX^® II

Recombinant Hepatitis B Vaccine, 10 micrograms/1 millilitre, Suspension for Injection, for Adults and Adolescents

2. Qualitative And Quantitative Composition

One dose of HB-VAX^® II contains:

Hepatitis B surface antigen, recombinant (HBsAg) * 10 micrograms

* Surface antigen of hepatitis B virus produced from recombinant strain of the yeast Saccharomyces cerevisiae (strain 2150-2-3).

For excipients, see 6.1.

3. Pharmaceutical Form

Suspension for injection.

4. Clinical Particulars

4.1 Therapeutic Indications

This vaccine is indicated for active immunisation against hepatitis B virus infection caused by all known subtypes in subjects considered at risk of exposure to hepatitis B virus.

Groups identified at increased risk of infection:

Health care personnel. Oral surgeons, dentists, physicians and surgeons, nurses, dental hygienists, paramedical personnel in close contact with patients, staff in haemodialysis, haematology and oncology units, laboratory personnel handling blood and other clinical specimens, emergency and first aid workers, ambulance staff, blood bank and plasma fractionation workers, cleaning staff in hospitals handling waste, chiropodists, morticians and embalmers.

Patients frequently receiving blood products. Patients in haemodialysis and oncology units, patients suffering from thalassaemia, sickle cell anemia, liver cirrhosis, haemophilia, and patients receiving frequent blood transfusion or clotting factor concentrates, patients receiving organ transplants.

Personnel collecting, sorting out, handling specific waste and household rubbish.

Personnel and residents of institutions. Persons with frequent and/or close contacts with high risk groups, prisoners and prison staff, residents and staff of institutions for mentally handicapped.

Persons at increased risk due to their sexual behaviour. Persons with multiple sexual partners, patients with a Sexually Transmitted Disease (STD), persons seeking treatment for an STD, prostitutes and male homosexuals.

Illicit users of addictive injectable drugs.

Travellers to areas with a high endemicity of HBV.

Persons originating from areas with a high endemicity of HBV. Adoptees, immigrants and refugees.

Others: police personnel, fire brigade personnel, armed forces personnel and anybody who through their work or personal lifestyle may be exposed to HBV.

Household contacts of any of the above groups and contacts with acute or chronic HBV infection.

Nevertheless, the recommendations should be adjusted in line with national vaccination policies since in some countries generalisation of vaccination is highly recommended.

4.2 Posology And Method Of Administration

Posology:

Adolescents and adults (16 years of age and older): 1 dose (10 micrograms) of 1 millilitre at each injection.

A course of vaccination should include at least three doses as follows:

1^st injection: at elected date

2^nd injection:

3^rd injection:

This schedule allows the incorporation of several schemes in national vaccination recommendations.

The most commonly used schedules in Europe are:

0 , 1, 6 months:

two injections with an interval of one month; a third injection 6 months after the first administration.

0 , 1, 2, 12 months:

three injections with an interval of one month; a fourth dose should be administered at 12 months.

The accelerated schedule (0, 1, 2 ,12 months) may induce protective antibody levels earlier in a slightly larger proportion of vaccinees.

Booster:

Immunocompetent vaccinees:

The duration of the protective effect of HB-VAX^®II in healthy vaccinees is unknown at present and the need for booster doses is not yet defined. However, some national vaccination schedules currently include recommendations for periodic booster doses.

Immunoincompetent vaccinees (e.g. dialysis patients):

A booster dose may be considered in these vaccinees if the anti-HBs level is less than 10 International Units/litre.

Special dosage recommendations for known or presumed exposure to HBV (e.g. needlestick with contaminated needle):

Hepatitis B immunoglobulin should be given as soon as possible after exposure (within 24 hours).

The first dose of the vaccine should be given within 7 days of exposure and can be given simultaneously with hepatitis B immunoglobulin, but administered at a separate injection site.

Subsequent doses of vaccine, if necessary, (i.e. according to the serologic status of the patient) should be given as in the recommended schedule for this vaccine.

Method of Administration:

This vaccine is for intramuscular injection. The deltoid muscle is the preferred site for injection in adolescents and adults.

Exceptionally, the vaccine may be administered subcutaneously in patients with thrombocytopenia or to persons at risk of haemorrhage.

4.3 Contraindications

• Severe febrile illness.

• Hypersensitivity to any component of the medicinal product or allergic reaction after previous vaccine administration.

4.4 Special Warnings And Precautions For Use

Because of the long incubation period of hepatitis B, it is possible for unrecognised hepatitis B infection to be present at the time of immunisation. The vaccine may not prevent hepatitis B infection in such cases.

The vaccine will not prevent infection caused by other agents such as hepatitis A, hepatitis C and hepatitis E and other pathogens known to infect the liver.

In dialysis patients and persons with an impaired immune system, administration of additional doses of vaccine may be needed to obtain a protective anti-HBs titre.

As with all injectable vaccines, appropriate medical treatment should always be readily available in case of rare anaphylactic reactions following the administration of the vaccine.

Exceptionally, the vaccine may be administered subcutaneously in patients with thrombocytopenia or to persons at risk of haemorrhage.

This vaccine contains thiomersal as a preservative.

This vaccine may contain traces of formaldehyde and potassium thiocyanate which are used during the manufacturing process.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

This vaccine can be administered with hepatitis B immunoglobulin (HBIg), at a separate injection site.

This vaccine can be used to complete a primary immunisation course or as a booster dose in subjects who have previously received another hepatitis B vaccine.

4.6 Pregnancy And Lactation

The effect of the HBsAg on foetal development has not been assessed. However, as with all inactivated viral vaccines, one does not expect harm for the foetus. Utilisation during pregnancy requires that the potential benefit justifies the potential risk to the foetus.

The effect of the administration of this vaccine on breast fed infants has not been assessed; nevertheless, this situation is not a contraindication.

4.7 Effects On Ability To Drive And Use Machines

There are no specific data. Some of the rare effects mentioned under 'Undesirable Effects', such as dizziness and headache, may affect the ability to drive or operate machinery.

4.8 Undesirable Effects

The following undesirable effects have been reported following the widespread use of the vaccine. As with other hepatitis B vaccines, in many instances, the causal relationship to the vaccine has not been established.

Common reactions:

Local reactions at the injection site: transient soreness, erythema, induration.

Very rare:

– elevation of liver enzymes, fatigue, fever, malaise, influenza-like symptoms, bronchospasm-like symptoms, serum sickness, thrombocytopenia

– dizziness, headache, paraesthesia

– nausea, vomiting, diarrhoea, abdominal pain

– arthralgia, arthritis, myalgia

– rash, alopecia, pruritus

– hypotension, syncope

– paralysis (Bell's palsy), peripheral neuropathies (polyradiculoneuritis, facial paralysis), neuritis (including Guillain-Barré Syndrome, optical neuritis, myelitis including transverse myelitis), encephalitis, demyelinating disease of the central nervous system, exacerbation of multiple sclerosis, multiple sclerosis, seizure

– urticaria, angioedema, erythema multiforme, anaphylaxis

– lymphadenopathy

– vasculitis

This medicinal product contains thiomersal (an organomercuric compound) as a preservative and therefore it is possible that sensitisation reactions may occur (see section 4.3)

4.9 Overdose

No case of overdose has been reported.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

J: ANTI-INFECTIOUS.

Vaccines/hepatitis B

The vaccine induces specific humoral antibodies against HBsAg (anti-HBs). Development of an anti-HBs titre above 10 International Units/litre measured 1-2 months after the last injection correlates with protection to HBV infection.

In clinical trials, 96% of 1497 healthy infants, children, adolescents and adults given a 3 dose course of HB-VAX^® II developed a protective level of anti-HBs (>10 International Units/litre).

The protective efficacy of a dose of hepatitis B immunoglobulin (HBIg) at birth followed by 3 doses of HB-VAX^® II has been demonstrated for neonates born to mothers positive for both HBsAg and HBeAg. Among 130 vaccinated infants, the estimated efficacy in prevention of chronic hepatitis B infection was 95% as compared to the infection rate in untreated historical controls.

Although the duration of the protective effect of HB-VAX^® II in healthy vaccinees is unknown, follow-up over 5-9 years of approximately 3000 high-risk subjects given a similar plasma-derived vaccine has revealed no cases of clinically apparent hepatitis B infection.

In addition, persistence of vaccine-induced immunologic memory for HBsAg has been demonstrated through an anamnestic antibody response to a booster dose of HB-VAX^® II in healthy adults given plasma-derived vaccine 5 to 7 years earlier.

5.2 Pharmacokinetic Properties

Not applicable.

5.3 Preclinical Safety Data

Animal reproduction studies have not been conducted.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Thiomersal, aluminium hydroxide, sodium chloride, sodium borate and Water for Injections.

6.2 Incompatibilities

The vaccine should not be mixed in the same syringe with other vaccines or parenterally administered drugs.

6.3 Shelf Life

Three years.

6.4 Special Precautions For Storage

Store between +2°C and +8°C.

DO NOT FREEZE.

6.5 Nature And Contents Of Container

1 millilitre of suspension in prefilled syringe (Type I glass) with attached needle and with a chlorobromobutyl stopper (unit pack).

1 millilitre of suspension in a vial (Type I glass).

6.6 Special Precautions For Disposal And Other Handling

Before use, the vaccine should be well shaken to obtain a slightly opaque white suspension.

7. Marketing Authorisation Holder

UK:	Ireland:
Aventis Pasteur MSD Limited Mallards Reach Bridge Avenue Maidenhead Berkshire SL6 1QP	Aventis Pasteur MSD Limited Belgard Road Tallaght Dublin 24

8. Marketing Authorisation Number(S)

UK:	Ireland:
PL 6745/0096	PA 544/23/5 (syringe only)

9. Date Of First Authorisation/Renewal Of The Authorisation

14 December 1993

10. Date Of Revision Of The Text

August 2000

11. LEGAL CATEGORY

POM

® Registered Trademark

4006556/HBV/RA284/0800/A

multivitamins with iron

Generic Name: multivitamin with iron (MUL tee VYE ta mins with i ron)

Brand names: Fero-Folic 500, Theragran Hematinic, ...show all 156 brand names.Iberet-Folic-500, Dialyvite, Chromagen FA (obsolete), Chromagen Forte (obsolete), TriHEMIC 600, Chromagen (obsolete), Nephro-Vite with Fe, Allbee-C 800 with Iron, Livitrinsic-F, Foltrin, Intrinsitinic, Ferotrinsic, Contrin, Trinsicon, Niferex-150 Forte (obsolete), Iberet-500, Generet-500 with Folic Acid, Vi-Daylin with Iron, Dayalets Plus Iron, Nephron-FA, Sesame St. Vitamins Plus Iron, Fe-Tinic 150 Forte, Equi-Roca Plus, Equicyte Plus, Poly-Vi-Sol with Iron Drops, Vi-Daylin with Iron Chewable, Femiron Multi with Iron, Garfield Vitamin with Iron, Vi-Daylin with Iron Drops, One Tab Daily with Iron, Bugs Bunny with Iron Chewable, Flintstones with Iron Chewable, Sunkist Child Chewable with Iron, Poly-Vi-Sol with Iron, Mult-Ferr Folic, Unicap with Iron, Icaps, Iberet, Stresstabs with Iron, Surbex-750 with Iron, Stress Formula with Iron, Geritol, SSS Tonic, Vi-Daylin ADC with Iron, Tri-Vi-Sol with Iron, Tab-A-Vite with Iron, Geri-Tabs, I-L-X, I-L-X and B12, Multibret Folic 500, IBC 500, Multiret Folic 500, Geravim, Chromatinic, Iromin G, Myferon 150 Forte, Hemocyte Plus (obsolete), Pronemia, Vi-Stress with Iron, Fumatinic, Therems H, Tolfrinic, Fruity Chews with Iron, Feocyte, Vita-PMS, Vita-PMS Plus, Ferocon, Anemagen, Nu-Iron Plus, Anemagen FA, Ferragen, Conison, Poly Iron 150 Forte, Iberet Liquid, Iberet-500 Liquid, Hemocyte-F Elixir, Diatx Fe, Icar-C Plus, Senilezol, Ferrogels Forte, Promar, Fetrin, Feogen, Proferrin-Forte, FoliTab 500, FE C Tab Plus, Icar-C Plus SR, Ferbee, Uni-Daily Plus Iron, Multifol, Irofol, Niferex(obsolete), Niferex-150 (obsolete), Uni Kar Plus C SR, Repliva 21/7, Niferex Gold, Tricon, Hematogen, Hematogen FA, Hematogen Forte, Iferex 150 Forte, Vita Drops with Iron, Niferex-150 Forte, Chromagen, Chromagen FA, Chromagen Forte, Ferrex 150 Forte, MyKidz Iron, Martinic, Apetimar with Iron, Vimar with Iron, Multi-Delyn with Iron, Maxaron Forte, Ferralet 90, Multigen, Multigen Plus, Anemagen Forte, Ferrex 150 Forte Plus, Good Sense Children's Vitamins with Iron, PruVate 21/7, Ferraplus, Multigen Folic, Integra Plus, Integra F, Integra, Vitagen Advance, Rexavite 150 Forte, Vitagen Forte, Trimagen, Trimagen Forte, Triferex 150 Forte, Se-Vate, Ferotrin, FerroVite, Ferroflex-150 Forte, FerroVite FA, FerroVite Forte, Ferrex 28, Trimagen FA, TL Icon, Suplevit, Folivan-F, Folivan-Plus, Taron Forte, Gentle Iron, BiferaRx, Lydia Pinkham, Trigels F, CorviteFE, Irospan 24/6, NovaFerrum, TL-Fol 500, Daily-Vite with Iron, Iron-150

What is multivitamin with iron?

Multivitamin are a combination of many different vitamins that are normally found in foods and other natural sources.

Iron is normally found in foods like red meat. In the body, iron becomes a part of your hemoglobin (HEEM o glo bin) and myoglobin (MY o glo bin). Hemoglobin carries oxygen through your blood to tissues and organs. Myoglobin helps your muscle cells store oxygen.

Multivitamin and iron are used to provide vitamins and iron that are not taken in through the diet. They are also used to treat iron or vitamin deficiencies caused by illness, pregnancy, poor nutrition, digestive disorders, and many other conditions.

Multivitamin and iron may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about multivitamin with iron?

Never take more than the recommended dose of a multivitamin. Avoid taking any other multivitamin product within 2 hours before or after you take multivitamin with iron. Taking similar vitamin products together at the same time can result in a vitamin overdose or serious side effects. Seek emergency medical attention if you think you have used too much of this medicine. An overdose of vitamins A, D, E, or K can cause serious or life-threatening side effects. Iron and other minerals contained in a multivitamin can also cause serious overdose symptoms if you take too much.

Overdose symptoms may include severe stomach pain, vomiting, bloody diarrhea, coughing up blood, constipation, loss of appetite, hair loss, peeling skin, warmth or tingly feeling, changes in menstrual periods, weight loss, severe headache, muscle or joint pain, severe back pain, blood in your urine or stools, black and tarry stools, pale skin, easy bruising or bleeding, weakness, shallow breathing, weak and rapid pulse, pale skin, blue lips, and seizure (convulsions).

Do not take this medication with milk, other dairy products, calcium supplements, or antacids that contain calcium. Calcium may make it harder for your body to absorb certain ingredients of the multivitamin with iron.

What should I discuss with my healthcare provider before taking multivitamin with iron?

Iron and certain vitamins can cause serious or life-threatening side effects if taken in large doses. Do not take more of this medication than directed on the label or prescribed by your doctor.

If you have any medical conditions, ask your doctor before taking a multivitamin with iron. If you have certain conditions, you may need a certain vitamin formulation or special tests while taking this product.

Do not take multivitamin with iron without telling your doctor if you are pregnant or plan to become pregnant. Some vitamins and minerals can harm an unborn baby if taken in large doses. You may need to use a prenatal vitamin specially formulated for pregnant women. Multivitamin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take multivitamin with iron?

Use this medication as directed on the label, or as your doctor has prescribed. Do not use the medication in larger amounts or for longer than recommended.

Never take more than the recommended dose of multivitamin with iron. Avoid taking any other multivitamin product within 2 hours before or after you take multivitamin with iron. Taking similar vitamin products together at the same time can result in a vitamin overdose or serious side effects.

Many multivitamin products also contain minerals such as calcium, magnesium, potassium, and zinc. Minerals (especially taken in large doses) can cause side effects such as tooth staining, increased urination, stomach bleeding, uneven heart rate, confusion, and muscle weakness or limp feeling. Read the label of any multivitamin product you take to make sure you are aware of what it contains.

Take your multivitamin with a full glass of water. You may take the multivitamin with food if it upsets your stomach.

The chewable tablet must be chewed or allowed to dissolve in the mouth before swallowing.

Measure the liquid form of this multivitamin using a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Liquid multivitamin may sometimes be mixed with water, fruit juice, or infant formula (but not milk or other dairy products). Follow the directions on the medicine label.

Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow the pill whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

It is important to take multivitamin with iron regularly to get the most benefit.

Store this medication at room temperature away from moisture and heat. Keep the liquid medicine from freezing.

Store multivitamin in their original container. Storing multivitamin in a glass container can ruin the medication.

See also: Multivitamins with iron dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of vitamins A, D, E, or K can cause serious or life-threatening side effects. Iron and other minerals contained in a multivitamin can also cause serious overdose symptoms.

Overdose symptoms may include severe stomach pain, vomiting, bloody diarrhea, coughing up blood, constipation, loss of appetite, hair loss, peeling skin, warmth or tingly feeling, changes in menstrual periods, weight loss, severe headache, muscle or joint pain, severe back pain, blood in your urine or stools, black and tarry stools, pale skin, easy bruising or bleeding, weakness, shallow breathing, weak and rapid pulse, pale skin, blue lips, and seizure (convulsions).

What should I avoid while taking multivitamin with iron?

Avoid taking any other multivitamin product within 2 hours before or after you take multivitamin with iron. Taking similar vitamin products together at the same time can result in a vitamin overdose or serious side effects.

Avoid the regular use of salt substitutes in your diet if your multivitamin contains potassium. If you are on a low-salt diet, ask your doctor before taking a vitamin or mineral supplement.

Avoid taking an antibiotic medicine within 2 hours before or after you take multivitamin with iron. This is especially important if you are taking an antibiotic such as ciprofloxacin (Cipro), demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), norfloxacin (Noroxin), ofloxacin (Floxin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

Certain foods can also make it harder for your body to absorb iron. Avoid taking this multivitamin within 1 hour before or 2 hours after eating fish, meat, liver, and whole grain or "fortified" breads or cereals.

Do not take this medication with milk, other dairy products, calcium supplements, or antacids that contain calcium. Calcium may make it harder for your body to absorb certain ingredients of the multivitamin.

Multivitamin with iron side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor if you have serious side effects such as:

• 
  

  bright red blood in your stools; or

  
  


• 
  

  pain in your chest or throat when swallowing a ferrous fumarate tablet.

  
  

When taken as directed, multivitamin are not expected to cause serious side effects. Less serious side effects may include:

• 
  

  constipation, diarrhea;

  
  


• 
  

  nausea, vomiting, heartburn;

  
  


• 
  

  stomach pain, upset stomach;

  
  


• 
  

  black or dark-colored stools or urine;

  
  


• 
  

  temporary staining of the teeth;

  
  


• 
  

  headache; or

  
  


• 
  

  unusual or unpleasant taste in your mouth.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Multivitamins with iron Dosing Information

Usual Adult Dose for Anemia:

Tablets or capsules:
1 tablet orally once daily or as indicated by individual product directions.

Oral liquid:
5 to 15 mL orally once daily or as indicated by individual product directions.

Usual Pediatric Dose for Anemia:

Tablets:
1 tablet orally once daily or as indicated by the individual product directions.

Drops:
0.5 to 1 mL orally once daily or as indicated by the individual product directions.

Oral liquid (100 mg elemental iron):
>= 12 yrs:
5 to 10 mL orally once daily or as indicated by the individual product directions.

What other drugs will affect multivitamin with iron?

Vitamin and mineral supplements can interact with certain medications, or affect how medications work in your body. Before taking multivitamin with iron, tell your doctor if you also use:

• 
  

  acetohydroxamic acid (Lithostat);

  
  


• 
  

  cimetidine (Tagamet);

  
  


• 
  

  deferoxamine (Desferal);

  
  


• 
  

  etidronate (Didronel);

  
  


• 
  

  diuretics (water pills);

  
  


• 
  

  heart or blood pressure medications;

  
  


• 
  

  tretinoin (Vesanoid);

  
  


• 
  

  isotretinoin (Accutane, Amnesteen, Clavaris, Sotret);

  
  


• 
  

  dimercaprol (an injection used to treat poisoning by arsenic, lead, or mercury);

  
  


• 
  

  penicillamine (Cuprimine);

  
  


• 
  

  pancrelipase (Cotazym, Creon, Ilozyme, Pancrease, Ultrase);

  
  


• 
  

  trimethoprim and sulfamethoxazole (Cotrim, Bactrim, Septra, TMP/SMX); or

  
  


• 
  

  an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others.

  
  

This list is not complete and there may be other medications that can interact with or be affected by multivitamin with iron. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More multivitamins with iron resources

• Multivitamins with iron Dosage
• Multivitamins with iron Use in Pregnancy & Breastfeeding
• Drug Images
• Multivitamins with iron Drug Interactions
• Multivitamins with iron Support Group
• 11 Reviews for Multivitamins with iron - Add your own review/rating

Compare multivitamins with iron with other medications

• Anemia
• Vitamin/Mineral Supplementation and Deficiency

Where can I get more information?

• Your pharmacist can provide more information about multivitamin with iron.

V.V.S.

Generic Name: triple sulfa vaginal (TRIH pull SUL fa)

Brand Names: Gyne Sulf, Sultrin Triple Sulfa, Trysul, V.V.S.

What is V.V.S. (triple sulfa vaginal)?

Triple sulfa is an antibacterial medication. It fights bacteria in the body.

Triple sulfa vaginal is used to treat vaginal infections caused by the bacteria Gardnerella vaginalis.

Triple sulfa vaginal may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about V.V.S. (triple sulfa vaginal)?

Use this medication for the full amount of time prescribed by your doctor or recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.

Avoid wearing tight-fitting, synthetic clothing (such as pantyhose) that does not allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.

Avoid getting this medication in the eyes, nose, or mouth.

What should I discuss with my healthcare provider before using V.V.S. (triple sulfa vaginal)?

Do not use triple sulfa vaginal if you have ever had an allergic reaction to it or to another sulfa-based medicine.

Triple sulfa vaginal is in the FDA pregnancy category C. This means that it is not known whether triple sulfa vaginal will be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant. Triple sulfa passes into breast milk and may affect a nursing baby. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.

How should I use V.V.S. (triple sulfa vaginal)?

Use triple sulfa vaginal exactly as directed by your doctor or follow the directions that accompany the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using this medication.

Insert the tablet or cream into the vagina using the applicator as directed. Triple sulfa vaginal is usually used twice a day, in the morning and evening.

Use this medication continuously for the prescribed amount of time, even during your menstrual period.

A sanitary napkin can be worn to prevent the medication from staining clothing but do not use a tampon.

If the infection does not clear up after one course of therapy has been finished, or if it appears to get worse, see your doctor. You may have another type of infection.

Avoid getting this medication in the eyes, nose, or mouth. Store triple sulfa vaginal at room temperature away from moisture and heat.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and apply only the next regularly scheduled dose. Do not use a double dose.

What happens if I overdose?

An overdose of triple sulfa vaginal is unlikely to occur. If you do suspect that a much larger than normal dose has been used or that triple sulfa vaginal has been ingested, contact an emergency room or a poison control center.

What should I avoid while using V.V.S. (triple sulfa vaginal)?

Avoid wearing tight-fitting, synthetic clothing (e.g., panty hose) that does not allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.

Avoid sexual intercourse or use a condom to prevent spreading the infection to a sexual partner.

V.V.S. (triple sulfa vaginal) side effects

Stop using triple sulfa vaginal and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives).

Other, less serious side effects may be more likely to occur. These include burning, itching, irritation of the skin, and an increased need to urinate.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect V.V.S. (triple sulfa vaginal)?

Avoid using other vaginal creams or douches during treatment with triple sulfa, unless otherwise directed by your doctor.

Drugs other than those listed here may also interact with triple sulfa vaginal. Talk to your doctor and pharmacist before taking any prescription or over the counter medicines, including herbal products.

Compare V.V.S. with other medications

• Bacterial Vaginitis

Where can I get more information?

• Your pharmacist has additional information about triple sulfa vaginal written for health professionals that you may read.

What does my medication look like?

Triple sulfa vaginal is available with a prescription under several brand names. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

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  Sultrin Triple Sulfa vaginal tablets

  
  


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  Sultrin Triple Sulfa vaginal cream

  
  


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  Dayto Sulfa vaginal cream

  
  


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  Gyne-Sulf vaginal cream

  
  


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  Trysul vaginal cream

  
  


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  V.V.S. vaginal cream